Phosphatase and Tensin Gene Associated with Features of Aggressive Prostate Cancer
Journal Title: Translational Research in Urology - Year 2021, Vol 3, Issue 1
Abstract
Introduction The current study examined the clinical impacts of phosphatase and tensin (PTEN) expression in prostate cancer (PCa) using immunohistochemistry. Methods 50 patients with a mean age of 66.4±7.3 years who had undergone prostatectomy surgery with the diagnosis of PCa, were enrolled in the study. We collected 50 paraffin blocks from the malignant part and 50 paraffin blocks from the healthy part of each patient’s prostate. We considered malignant and healthy parts as the case and the control, respectively. Clinical and pathological information about the patients were gathered and their associations with PTEN status were assessed using odds ratios (ORs) analysis. Results The significant associations between tumor stage, perivascular invasion, perineural invasion, marginal involvement, extraprostatic extension, and biochemical recurrence (as assed by post-surgical prostate-specific antigen (PSA)) and PTEN expression were detected. For patients negative for PTEN, the odds ratio of the higher stage, perivascular invasion, perineural invasion, marginal involvement, and extraprostatic extension in comparison to patients positive for PTEN were estimated at 7.5 (95%CI: 2.01,27.86), (95%CI: 1.65-25.57), 7.8 (95%CI:1.54-40.09), 9.78 (95%CI:2.33-41.08), and 4.84 (95%CI:1.07-21.84), respectively. Concerning biochemical recurrence, ORs were calculated at 0.30 (95%CI:0.09-1.02) for PTEN-positive patients compare to PTEN-negative patients. Conclusions Since PTEN loss was associated with features of aggressive PCa, it can be concluded that loss of PTEN would lead to more aggressive PCa and thereby, lower clinical outcomes.
Authors and Affiliations
Mojtaba Saadati, Saeed Tamehri, Mohsen Pour Kamali, Diana Taheri
Keywords
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- EP ID EP704075
- DOI 10.22034/TRU.2021.276823.1062
- Views 133
- Downloads 0
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