Photostability of triazole antifungal drugs in the solid state
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2013, Vol 26, Issue 3
Abstract
The publication is devoted to photostability assessment of four triazole antifungal drugs: fluconazole, itraconazole, posaconazole and voriconazole. The compounds were exposed in the solid state using the whole spectrum of UV-Vis radiation. The analyses were performed using high performance thin layer chromatography (HPTLC) technique with densitometric detection. The results indicates considerable degradation of structurally similar itraconazole and posaconazole which could be clinically significant. After 72 hours of itraconazole irradiation there remain less than 25%, and 60% in case of posaconazole. To a lesser extent photodegradation concern two other compounds with a separate chemical structure: fluconazole and voriconazole. After 72 hours of irradiation there left 75% and 82% of these substances, respectively. The strict dependence between compound photostability and its chemical structure was observed.
Authors and Affiliations
Radosław J. Ekiert, Jan Krzek
Keywords
Related Articles
- EP ID EP88918
- DOI -
- Views 136
- Downloads 0
Pharmacies in Puławy - from the earliest times, to the nationalization of pharmacies
The beginnings of pharmacy in Puławy are associated with the family of the Czartoryski princes. They established the pharmacy “Pod Gwiazdą” in 1792, and Franciszek Ksawery Wasilewski, Piotr Garski and Ignacy Adam Mikołaj...
Simultaneous determination of amlodipine and telmisartan from pharmaceutical products by way of capillary electrophoresis
A rapid, simple and sensitive capillary zone electrophoresis method was developed for the simultaneous determination of amlodipine besylate and telmisartan, in fixed-dose combinations, through the utilization of a UV pho...
BMI in patients with obstructive sleep apnea
Obstructive sleep apnea (OSA) is a disease of multicasual etiology. The risk factors include obesity, among other issues. Hence, it is extremely important to determine the effect of body weight on the severity of OSA. Th...
Can chronic failure induce kidney function damage?
DOI: 10.1515/cipms-2016-0007 Accelerated atherosclerosis and increased cardiovascular events have been extensively documented in patients with end stage chronic kidney disease. The aim of our work was to find eviden...
Blood serum vitamin D status evaluated in healthy people
The purpose of the study was to evaluate the status of vitamin D in healthy subjects. Vitamin D level was determined on the basis of blood serum 25(OH)D concentrations, taking into account the time of blood collection an...