PHYSICOCHEMICAL CHARACTERIZATION OF AMORPHOUS SOLID DISPERSION OF KETOPROFEN–POLYVINYLPYRROLIDONE K-30
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 2
Abstract
Objective: The aim of the current study was to prepare an amorphous solid dispersion of ketoprofen in polymer PVP K-30 by solvent co-evaporation technique and to characterize the physicochemical properties. Methods: An amorphous solid dispersion of ketoprofen, a water insoluble non-steroidal anti- inflammatory drug with polyvinyl pyrrolidone K-30, were prepared by solvent co-evaporation method at drug to polymer ratios 1:1, 1:3, 1:5 and 1:9 (w/w). Physicochemical properties of the solid drug were evaluated by X-ray powder diffractometry (XRPD), differential thermal analysis (DTA) and scanning electron microscopy (SEM). Dissolution studies were conducted according to the USP paddle method.Results: The X-ray powder diffraction and differential thermal analysis showed that ketoprofen was transformed from a crystalline phase to an amorphous state, as showed by disappearance of its characteristic of diffraction peaks and an endothermic peak. SEM Microphoto of amorphous solid dispersion showed homogeneous size and morphology. In addition, ketoprofen in amorphous solid dispersion showed better dissolution rate compared to crystalline drugs. The dissolution efficiency (DE) of ketoprofen from its amorphous solid dispersion increased with an increasing ratio of polymer.Conclusion: The study has shown that dispersions of ketoprofen into water-soluble polymer PVP K-30 formed an amorphous ketoprofen in solid dispersion system. All amorphous solid dispersion of ketoprofen in PVP K-30 prepared by solvent co-evaporation demonstrated a significant improvement in dissolution rate of ketoprofen compared to pure ketoprofen.Â
Authors and Affiliations
Salman . , Ardiansyah . , Ellyza Nasrul, Harrizul Rivai, Elfi Sahlan Ben, Erizal Zaini
Keywords
Related Articles
- EP ID EP579065
- DOI -
- Views 80
- Downloads 0
DECITABINE FOR MYELODYSPLASTIC SYNDROME AND ELDERLY ACUTE MYELOID LEUKEMIA -A TERTIARY CENTRE DATA FROM INDIA
Objective: To assess the clinical profile of patients receiving Decitabine for myelodysplastic syndromes (MDS) and Acute myeloid leukemia (AML).Methods: 14 patients had been initiated on Decitabine which included 11 MDS...
CHEMICAL COMPOSITION, ANTIOXIDANT, ANTIBACTERIAL AND CYTOTOXICITY ANALYSIS OF BLUMEA LACERA (BURM. F.) DC
Objective: To investigate the in vitro antibacterial and antioxidant potential of B. lacera (leaves). The most active extracts were examined for their chemical composition and cytotoxicity.Methods: The antibacterial acti...
ANTIBACTERIAL ACTIVITIES OF SCYTONEMA HOFMAN EXTRACTS AGAINST HUMAN PATHOGENIC BACTERIA
Objective: The present study is focused, to evaluate the effectiveness of organic solvent or aqueous extracts of Scytonema hofman against some human bacterial pathogens.Methods: The aqueous and organic solvent extracts o...
PROTEOMIC ANALYSIS OF HUMAN BLOOD AND URINE IN DIABETIC NEPHROPATHY
Objective: To investigate the proteomics status of human blood and urine in diabetic nephropathy.Methods: In the present study 90 patients were selected. The study was comprised of 30 Diabetic mellitus (DM) with microalb...
STROKE OUTCOMES IN NON-DIABETIC, DENOVO DIABETIC AND DIABETIC INDIAN PATIENTS MEASURED BY MODIFIED RANKIN SCALE: AN OBSERVATIONAL STUDY
Objective: Hyperglycemia is a known risk factor which adversely impacts the outcomes in stroke patients compared to patients with normal blood glucose levels. Patients suffering from an acute stroke who are previously no...