Phytochemical screening and anticonvulsant activity of Sargassum ilicifolium (brown algae) in mice
Journal Title: The Journal of Phytopharmacology - Year 2018, Vol 7, Issue 1
Abstract
Sargassum ilicifolium (SI) is a tropical and subtropical marine macroalgae (brown algae) found in coastal area of India. Thais study investigated the anticonvulsant activity of SI in maximal electroshock (MES) induced convulsion and pentylenetetrazole (PTZ) induced convulsion in mice. The result of present study indicated that chloroform extract (600 mg/kg) and ethanol extract (400 mg/kg and 600 mg/kg) of SI significantly decreased the duration of tonic hind limb extension in MES model, as well as it significantly increased the latency to onset of convulsions in PTZ model. These results were comparatively similar with the effect of phenytoin (25 mg/kg) and phenobarbitone (20 mg/kg). This activity may be due to the presence of alkaloids, terpenoids, flavonoids, steroids and saponin in chloroform and ethanol extract of Sargassum ilicifolium. However, further research will be necessary to investigate the exact mechanism underlying this anticonvulsant activity.
Authors and Affiliations
Subhash R. Yende, Uday N. Harle, Sumit K. Arora, Vipinchandra B. Pande
Keywords
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