PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTIOXIDANT PROPERTIES OF SECONDARY METABOLITES IN AQUEOUS EXTRACTS OF FICUS THONNINGII BLUME TESTED ON WISTAR RATS

Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2019, Vol 6, Issue 2

Abstract

Introduction: Traditional medicine methods have had a very long history to treat every sort of health disorder. The World Health Organization estimates that around 80 % of the world population in developing countries relies on traditional plant medicines for primary health care needs, of which a major proportion corresponds to plant extracts or their active principles. Plants and herbs have been used since ancient times to treat different gastrointestinal illnesses, including peptic ulcers. Objective: To identify the major classes of secondary metabolites and evaluate the antioxidant property of the aqueous extracts of Ficus thonningii. Methods: The phytochemical screening of the extracts was done using the Odebiyi and Sofowora method. Various biochemical parameters such as the Malondialdehyde (MDA), Catalase, Glutathione, Superoxide dismutase (SOD), Xanthine Oxidase (XO), were quantified using standard regulatory techniques. Results: The phytochemical screening of the extract of the F. thonningii stem bark showed the presence of the sapononins, quinones, coumarins, catechic tannins, phlobotanins, anthocyanins, flavonoids and betacyanes. The extract resulted in a non-significant increase of SOD, Catalase and glutathione in the preventive and curative activity. There was a dose-dependent significant decrease in MDA P<0.05. The MDA content was higher in the group receiving the extract 500 mg/Kg, omeprazole and healthy animals, but lower in the negative control group. Conclusion:The phytochemical screening of the extract of the bark showed the presence of the saponins, quinones, coumarins, catechic tannins, phlobotanins, anthocyanin, polyphenols, flavonoïds and betacyanes. The extract resulted in a non-significant increase of SOD, Catalase and glutathione with a dose dependent decrease in MDA. The administration of this extract with 2000 mg/Kg dose was well tolerated with no lethality observed.

Authors and Affiliations

Charles Ntungwen Fokunang

Keywords

Related Articles

SYNTHESIS, REACTIVITY, ANTI-OXIDANT AND CYTOTOXICITY EVALUATION OF SOME COUMARIN DERIVATIVES

In the present work 3-amino-8-methoxy coumarin was prepared either by microwave irradiation or by convential method. It was used as a key starting material for the synthesis of triazole thione (8), Schiffs’ bases (10), t...

PREOPERATIVE DETECTION OF LYMPH NODES METASTASIS IN PATIENTS WITH PAPILLARY THYROID CARCINOMA

Background: Thyroid cancer is the most common endocrine malignancy and there have been a steady increase in its incidence over the past 15-20 years, It accounts for approximately 1% of all malignancies in developed count...

KNOWLEDGE OF SURGICAL CARE AMONG GENERAL POPULATION IN SAUDI ARABIA

Introduction: In Saudi Arabia, the overall number of surgical interventions performed in 2013 was 942609. There are no adequate information about knowledge and attitudes towards surgical care in Saudi community. This stu...

BENIGN INFLAMMATORY CERVICAL SMEAR IN A BACKGROUND OF NORMAL DIAGNOSTIC DILATATION AND CURETTAGE FINDING - A RARE PRESENTATION OF ENDOMETRIAL CARCINOMA

Endometrial carcinoma is a primary tumor of the uterus that usually presented with abnormal uterine bleeding commonly in post-menopausal woman. However, it can also manifests as abnormal cervical cytology even in a pre-m...

EARLY INFANT DETECTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION USING DRIED BLOOD SPOTS AT A TERTIARY CARE HOSPITAL IN RIVERS STATE, NIGERIA

Children born to HIV-positive mothers are likely to acquire maternal antibody which has made early infant detection of HIV challenging, using conventional screening methods. This study was aimed to provide early diagnosi...

Download PDF file
  • EP ID EP672607
  • DOI -
  • Views 163
  • Downloads 0

How To Cite

Charles Ntungwen Fokunang (2019). PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTIOXIDANT PROPERTIES OF SECONDARY METABOLITES IN AQUEOUS EXTRACTS OF FICUS THONNINGII BLUME TESTED ON WISTAR RATS. European Journal of Pharmaceutical and Medical Research, 6(2), 121-129. https://www.europub.co.uk/articles/-A-672607