PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTIOXIDANT PROPERTIES OF SECONDARY METABOLITES IN AQUEOUS EXTRACTS OF FICUS THONNINGII BLUME TESTED ON WISTAR RATS

Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2019, Vol 6, Issue 2

Abstract

Introduction: Traditional medicine methods have had a very long history to treat every sort of health disorder. The World Health Organization estimates that around 80 % of the world population in developing countries relies on traditional plant medicines for primary health care needs, of which a major proportion corresponds to plant extracts or their active principles. Plants and herbs have been used since ancient times to treat different gastrointestinal illnesses, including peptic ulcers. Objective: To identify the major classes of secondary metabolites and evaluate the antioxidant property of the aqueous extracts of Ficus thonningii. Methods: The phytochemical screening of the extracts was done using the Odebiyi and Sofowora method. Various biochemical parameters such as the Malondialdehyde (MDA), Catalase, Glutathione, Superoxide dismutase (SOD), Xanthine Oxidase (XO), were quantified using standard regulatory techniques. Results: The phytochemical screening of the extract of the F. thonningii stem bark showed the presence of the sapononins, quinones, coumarins, catechic tannins, phlobotanins, anthocyanins, flavonoids and betacyanes. The extract resulted in a non-significant increase of SOD, Catalase and glutathione in the preventive and curative activity. There was a dose-dependent significant decrease in MDA P<0.05. The MDA content was higher in the group receiving the extract 500 mg/Kg, omeprazole and healthy animals, but lower in the negative control group. Conclusion:The phytochemical screening of the extract of the bark showed the presence of the saponins, quinones, coumarins, catechic tannins, phlobotanins, anthocyanin, polyphenols, flavonoïds and betacyanes. The extract resulted in a non-significant increase of SOD, Catalase and glutathione with a dose dependent decrease in MDA. The administration of this extract with 2000 mg/Kg dose was well tolerated with no lethality observed.

Authors and Affiliations

Charles Ntungwen Fokunang

Keywords

Related Articles

DRUG ADDICTION AMONG INPATIENT AND OUTPATIENT CASES IN BAGHDAD

Introduction: Drug addiction is a mental or physical disorder caused by a defect in certain centers of the brain that results in the illegal dependence on medicine. Aims: To assess the drug addiction among people in Bagh...

ASSOCIATION OF UBE2L3 GENE POLYMORPHISM AND INTERLEUKIN 10 GENE POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS AMONG WOMEN POPULATION IN CHINA

Objective: To investigate the association of UBE2L3 gene polymorphism and Interleukin 10 gene polymorphism with systemic lupus erythematous among woman population in china. Methods: A case-control study of 111 female SL...

ANTIBACTERIAL ACTIVITY OF THE LEAF FRACTIONS OF ALCHORNEA CORDIFOLIA AGAINST ISOLATES FROM PATIENTS WITH RESPIRATORY TRACT INFECTION IN AHMADU BELLO UNIVERSITY TEACHING HOSPITAL ZARIA, NIGERIA

Background: Recent years have witnessed a dramatic increase in antibacterial resistance and a decline in the development of novel antibiotics. This problem is prevalent among common etiologic pathogens associated with Re...

EXTRACORPORAL IMMUNOPHARMACOTHERAPY IN COMPLEX TREATMENT OF CERVICAL CANCER AND OVAR CANCER

When prescribing EIPHT methods for patients with cervical cancer and OC, the results of clinical and diagnostic studies, anamnestic data, the presence of specific antitumor or nontraditional types of treatment before adm...

KNOWLEDGE, BELIEVES AND BEHAVIORS OF UNIVERSITY STUDENTS TOWARD OSTEOPOROSIS

Background: Osteoporosis is a rapidly growing chronic disease that progresses silently among women and the elderly increasing the burden on the global healthcare systems. Medical students are considered the channel throu...

Download PDF file
  • EP ID EP672607
  • DOI -
  • Views 166
  • Downloads 0

How To Cite

Charles Ntungwen Fokunang (2019). PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTIOXIDANT PROPERTIES OF SECONDARY METABOLITES IN AQUEOUS EXTRACTS OF FICUS THONNINGII BLUME TESTED ON WISTAR RATS. European Journal of Pharmaceutical and Medical Research, 6(2), 121-129. https://www.europub.co.uk/articles/-A-672607