Phytochemical screening, antiplatelet activity of Carica papaya leaf extract
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 4, Issue 3
Abstract
Carica papaya is belonging to family Caricaceae and it commonly known as papaya. Carica papaya leaves contain chemical constituents like carpine, psedo carpain, and dehydrocarpine I and II, carposide, vitamin C and vitamin E. Leaves of C. papaya used to Increase appetite, Ease menstrual pain, Meat tenderizer, Relieve nausea, in dengue fever. In the present study Carica papaya leaves extracts are prepared with methanol and water by soxhalation, the extracts are investigated for Phytochemicals and studied for invitro anti platelet activity by adrenaline induced platelet aggregation and calcium chloride induced platelet aggregation models. Both methanol and aqueous extracts are shown dose dependent platelet aggregation inhibition. More over Methanol extract shown good inhibition of platelet aggregation (65.63%) & (66.32%) than the aqueous extract (51.39%) & (62.85%) with 300µg/ml concentration than the control group, Aspirin is used as standard drug with 100μg/ml concentration and it showed inhibitory of Platelet aggregation (68.40%) & (68.68%) for both adrenaline induced and calcium chloride induce models simultaneously.
Authors and Affiliations
Narayanarao Alla, Satyanarayana T, Shara T, Naresh B, Nagaraju M, Himabindu J, Reshma Md
Keywords
Related Articles
- EP ID EP33388
- DOI -
- Views 276
- Downloads 0
Development and optimization of Diltiazem hydrochloride loaded microspheres by using different Eudragit polymers
The problems of frequent administration and variable low bioavailability (40-60%) after oral administration of conventional dosage forms of Diltiazem hydrochloride can be attenuated by designing it in the form of micro...
FORMULATION AND EVALUATION OF BILAYER TABLET OF CONVENTIONAL RELEASE PARACETAMOL AND MODIFIED RELEASE DICLOFENAC SODIUM
The present study deals with formulation and evaluation of bilayer tablet of paracetamol and diclofenac sodium to provide control over release of drug and to maintain the drug concentration. The major ingredients are p...
DEVELOPMENT AND VALIDATION OF PEMETREXED BY RP-HPLC METHOD IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORMS
A simple rapid, accurate, precise and reproducible validated reverse phase HPLC method was developed for the determination ofCeftazidimepentahydrate and Tazobactam sodium in bulk and pharmaceutical dosage forms. The qu...
Analytical method development and validation for the estimation of Olmesartan medoxomil by RP-UPLC in bulk and pharmaceutical dosage forms.
A simple rapid, accurate, precise and reproducible validated reverse phase UPLC method was developed for the determination of Olmesartan medoxomil in bulk and pharmaceutical dosage forms. The quantification was carried...
Investigation of Oxygen absorbent in food packages
Active packaging is one of the newest concepts in food packages uses in order to supply the customer demands in shortest time. To prepare targeted foods, globalization of food market, transferring to longer distances,...