PHYTOCHEMICAL STUDY AND ANTIMICROBIAL ACTIVITIES OF CORDIA DICHOTOMA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 12
Abstract
The present study was aimed at detecting the phytochemicals and evaluating antimicrobial activities of Cordia dichotoma known for their medicinal properties in folk medicine. Phytochemical screening was carried out on the leaves of Cordia dichotoma; the results latifoliate the presence of alkaloids, proteins, carbohydrates. The assessment of antifungal activity was performed in terms of percentage of radial growth on solid medium (potatoes dextrose agar PDA) against Aspergillus flavus and Penicillium expansum. The antibacterial effect was studied by the agar direct contact method using Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia colistrains. The phytochemical estimation revealed the presence of alkaloids, flavonoids and saponosides. These phytochemicals were isolated from the plant with yields of 5.709 % of Petroleum ether extract, 6.69 % of Chloroform extract, and 9.45 % of methanol extract. Finally, the results of antimicrobial activity of the aqueous extract showed a pronounced antifungal activity against the tested strains. The percentage inhibition values were found to be in the range of 12-24 mm against Candida albicans and 11 to 19 mm against Aspergilus niger. The results revealed that the methanolic extract exhibited significant antimicrobial activity of concentration of 100-500 μ/ml respectively against tested organisms, particularly more effective against Bacilus cereus and Escherichia coli than the other extract when compared to the standard drug (chloramphenicol).
Authors and Affiliations
Suman Rawat , Ruchi Saini , Ankita Sharma
Keywords
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- EP ID EP115544
- DOI 10.7897/2230-8407.041212
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