Plant-derived Tetranortriterpenoid, Methyl Angolensate Activates Apoptosis and Prevents Ehrlich Ascites Carcinoma Induced Tumorigenesis in Mice
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 12, Issue 11
Abstract
Background: Cancer is a leading health problem throughout the world. For decades, natural plant products have been playing promising roles as anticancer agents. Objective: The present study aims to investigate the chemotherapeutic potential of methyl angolensate (MA), purified from Soymida febrifuga in mice bearing carcinoma and examines the molecular basis for its anticancer actions. Study Design: The inhibitory effects of MA treatment on the survival of mice bearing Carcinoma and adverse side effects of MA treatment in mice were analyzed. Methods: Tumor volume, life span, histopathology, immunohistochemical (IHC) analysis, estimation of liver enzyme, alkaline phosphatase and metabolites, creatinine and urea. Results: Oral administration of MA in mice with Ehrlich Ascites Carcinoma showed significant inhibition of tumor growth compared to untreated mice. We observed a significant increase in the life span (~4-fold) of tumor bearing animals following treatment with MA. MA affected tumor cell proliferation by activating intrinsic pathway of apoptosis without imparting any side effect on normal cells. MA treatment in mice showed no major side effects. Conclusion: MA treatment showed significant inhibition of tumor growth by inducing apoptosis as well increased life span of mice, with no adverse side effects to normal cells. Altogether, the present in vivo study provides new insights of MA serving as a cancer chemotherapeutic agent.
Authors and Affiliations
Kishore K. Chiruvella, Mayilaadumveettil Nishana, Vidya Gopalakrishnan, Somasagara R. Ranganatha, Satish Kumar Tadi, Bibha Choudhary, Sathees C. Raghavan
Effect of Pentoxifylline on Experimental-dextran Sulphate Sodium-induced Colitis in Rats
Aims: Ulcerative colitis (UC) is considered as an idiopathic, chronic inflammatory bowel disease (IBD) with multifactorial agents. Tumor necrosis factor-alpha (TNF-α) has been suggested to be one of them. The study was d...
Evidence Based Medicine: Assessing Knowledge, Attitudes and Barriers in Post-graduate Training
Aims: To assess the knowledge and attitude of post- graduate medical students regarding evidence based medicine (EBM) and to find out the barriers against its implementation, if any. Study Design: Medical college based c...
Comparison of Cardiac Function Evaluation by 128-Slice Single Source Retrospectively Gated Cardiac CT and 2D/M- mode Echocardiography
Aims: To study the correlation of Cardiac function/ejection fraction derived from 128 slice MDCT (multi detector computed tomography) results with those of functional data from 2D/M-mode echocardiography. Study Design: R...
Prevalence of Hypertension Stages and the Main Risk Factors in Khartoum Locality, Sudan, 2014
Background Information: Cardiovascular diseases (CVDs) are number one killer in the world among non-communicable diseases (NCDs). The principal underlying risk factor for CVDs is hypertension (HTN). Objectives: To ident...
Prescription Pattern Study in Type 2 Diabetes Mellitus in Diabetic out Patients in Private Clinics in Kerman, Iran
Aims: Diabetes mellitus (DM) is a chronic disease associated with significant morbidity and mortality. The present study was carried out to assess prescribing practice for oral antidiabetic drugs in type 2 diabetes melli...