Plasma Cholesterol Profile And Their Internal Ratio In Type-2 Diabetes Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Diabetes mellitus induced dyslipidemia is the root cause of life threatening micro and macro vascular complications in type-2 diabetic subjects. The principle predictor of diabetes induced cardio vascular complications which are normally employed are becoming less consistent due to use of various lipid lowering agents. It has been suggested that plasma triacylglycerol levels alone is an independent risk factor of cardio vascular complications in diabetes mellitus. The cholesterol profile and their internal ratios may through much light on prediction of dyslipidemia induced cardio vascular complications in diabetes mellitus. Hence a study was planned to assess the plasma cholesterol profile and their internal reciprocals in type-2 diabetes mellitus. A fasting blood sample from both Normal subjects(n=95) and from type-2diabetic subjects(n=132) was collected and was employed for estimation of cholesterol profile as well as triacylglycerol levels. The results indicate a significant(p<0.001) fall in the ratio of total cholesterol/VLDL cholesterol in type-2 diabetic subjects of both sexes as compared to normal subjects indicating this ratio is a determinant of diabetes induced dyslipidemia and may be clinically employed as significant predictor of dyslipidemia induced complications in type-2 diabetic subjects.
Authors and Affiliations
Nagendra. S, Srinivas S, Kashinath R T
Keywords
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- EP ID EP244443
- DOI 10.9790/0853-1610105055
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