Pochodne 1,2,3-triazolu. Potencjalne leki?
Journal Title: Wiadomości Chemiczne - Year 2012, Vol 66, Issue 11
Abstract
Recently, 1,2,3-triazoles have gained an increased attention in the field of drug discovery because several derivatives have already been marketed as medications (e.g. tazobactam, cefatrizine, rufinamide) [1, 2] and many of them appeared to be very active in diverse biological studies including plinambulin 69 currently in the last stage of the clinical trials [60]. In this review very recent investigations of antibacterial, antitubercular, antifungal, antipsychotic, antiepileptic, anti-inflammatory, hypoglycemic, anticancer and antiviral properties of 1,2,3-triazole derivatives are discussed. These studies allowed to select several compounds which were found to be more active in comparison to the already used drugs.
Authors and Affiliations
Emilia Bankowska, Andrzej E. Wróblewski
Keywords
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