POEMS syndrome with hepatosplenomegaly as the initial manifestation： A report of two cases
Journal Title: Journal of Clinical Hepatology - Year 2025, Vol 41, Issue 1
Abstract
POEMS syndrome is a rare condition associated with plasma cell disorders， and it often involves multiple systems and has diverse clinical manifestations. This article reports two cases of POEMS syndrome with hepatosplenomegaly as the initial manifestation. During the course of the disease， the patients presented with lower limb weakness， hepatosplenomegaly， lymph node enlargement， ascites， hypothyroidism， positive M protein， and skin hyperpigmentation， and 18F-FDG PET-CT imaging revealed bone lesions mainly characterized by osteolytic changes and plasma cell tumors. There was an increase in the serum level of vascular endothelial growth factor. The patients were finally diagnosed with POEMS syndrome， and the symptoms were relieved after immunomodulatory treatment.
Authors and Affiliations
Ye ZHANG, Wenqing WANG, Jing LI, Qianrong BAI, Jiayu LI, Yan CHENG, Miaomiao FANG, Nana GAO, Changxing HUANG
Keywords
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- EP ID EP768417
- DOI 10.12449/JCH250119
- Views 9
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