Polyherbal Extract of Ocimum Gratissimum and Gongronema Latifolium on Reproductive Functions in Alloxan Induced Diabetic Male Rats
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 4
Abstract
Background: Reproductive functions are impaired in diabetes mellitus. Polyherbal extracts from ocimum gratissimum and gongronema latifolium extracts on reproductive hormones and sperm parameters were studied in alloxan induced diabetic rats. Materials and Methods: Twenty five adult male albino rats were used in the study. Twenty rats were made diabetic using 100 mg/kg body weight of alloxan monohydrate (intraperitoneal injection). The rats were divided into five groups I (control), II (diabetic control), III, IV and V. The rats were treated with 200mg/kg of ocimum gratissimum (group III), 200mg/kg of gongronema latifolium (group IV), and 200mg/kg per extract of ocimum gratissimum and gongronema latifolium (group V) for 21 days. Results: The rats treated with polyherbal extracts showed significantly reduced levels of FSH, LH, testosterone, sperm count, sperm motility, sperm morphology and viability. The same results was obtained in rats treated with gongronema latifolium (200mg/kg) except in rats treated ocimum gratissimum extract (200mg/kg) that showed elevated testosterone levels. Conclusion: These findings showed that polyherbal treatment from ocimum gratissimum and gongronema latifolium do not restore reproductive functions in alloxan induced diabetic rats
Authors and Affiliations
Agbai Emmanuel Onuka
Keywords
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