POLYMER CROSS LINKED SILK PROTEIN AS A PHARMACEUTICAL EXCIPIENT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 1
Abstract
Silk proteins are natural proteins in silk cocoons. Silk cocoons contain 25% - 30% of sericin, remaining is constituted by fibroin. The present study aims to extract the sericin and cross link it with suitable polymers. And study the influence of cross linked sericin on tablet properties. Sericin was extracted and was cross linked with Gelatin, Gurgum, PVP, Acrylamide. Cross linked sericin was evaluated for binding property of tablets. It was found that sericin loses its binding efficiency by cross linking it with selected polymer. Presence of cross linked sericin in tablet formulation did not influence the dissolution of either the water soluble drug (propranolol HCl) or water insoluble drug (indomethacin). However sericin cross linked with acrylamide retarded drug release. It may be due to formation of Inter Penetrating Polymer Network (IPN). Cross linked sericin could not satisfy the requirements of pharmaceutical excipient for oral solid dosages form. Cross linked sericin with acrylamide exhibited swelling property can further explored for topical controlled release.
Authors and Affiliations
Gouri Shankar , Parthasarathi Kulkarni , Ajay Kulkarni , Mudit Dixit
Keywords
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