Polymorphism rs3087243 is associated with the occurrence of ankylosing spondylitis in the West Algerian population
Journal Title: UNKNOWN - Year 2017, Vol 1, Issue 2
Abstract
Background: Numerous studies have shown that polymorphism rs231775 of the CTLA4 gene is strongly implicated in the development of ankylosing spondylitis (AS). Other polymorphisms of this gene are candidates that may have an additional effect in susceptibility to AS. For the first time, we searched for the association of rs3087243 polymorphism located in the 3'UTR region of the CTLA4 gene with the development of SA in the Algerian population. Methods: The study involved 200 subjects (80 AS patients recruited at the rheumatology service and 120 healthy individuals unrelated). Genotyping was performed by real-time PCR (Taqman®). Analysis of the results was carried out by IBM.SPSS.Statictis® software. Results: The distribution of allele frequencies showed a significant association between the GG genotype of the polymorphism rs3087243 and AS risk (OR= 1.77 [0.98-3.21], p=0.004). Conclusion: Our data would suggest that the 3'UTR region of the CTLA4 gene could have an impact on the development of SA in the West Algerian population. These results need to be confirmed on a larger sample.
Authors and Affiliations
Chahinez Amira DAHMANI, Elisabeth PETIT-TEIXEIRA, Abdallah BOUDJEMA
Keywords
Related Articles
- EP ID EP261226
- DOI 10.26415/2572-004X-vol1iss2p29-30
- Views 54
- Downloads 0
Colorectal Cancers Screening in the General Population: Focusing
Colorectal cancers are common throughout the world, although their incidence varies across continents and countries. 28% of these cancers are rectal, and two-thirds of the remaining 72% are of left colonic location. Scre...
Optimization of environmental parameters followed for better clinical urolithiasis in Western Algeria
Medicine attaches great importance to the influence of environmental and human health measures recommended to minimize problems related to the environment. One of the oldest diseases mentioned and described by doctors si...
Research of the yeasts Candida non - albicans on various medical devices in the service of resuscitation of the Teaching hospital of Tlemcen, Algeria
Background and aim: The fungic infections, more particularly the Candidiasis are frequent in the intensive care units. This had a relation with the heaviness of the pathologies, presented by the patients and the quasi-sy...
Contextual hybrid-based recommendation of Pubmed articles
Background: The amount of information in the medical field has been growing day by day. Also new medical articles about the preoccupied disease are published each day and the updated information is very required by physi...
Biocontrol from Rosmarinus officinalis extracts against pathogen fungi
Rosmarinus officinalis is widely used for his anti-microbial activities .To this aim aqueous methanolic and methanolic sonicaded extracts of these plant were tested in vitro against deferent pathogenic strain...