Post Autologous Stem Cell Transplantation Maintenance for Multiple Myeloma Patients: Real World Experience and Results
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 13, Issue 5
Abstract
Maintenance therapy is routinely prescribed for multiple myeloma (MM) patients after autologous stem cell transplantation (ASCT). In this retrospective analysis, we evaluated 257 post-ASCT MM patients and compared the effect of various maintenance therapies used in our institution. These include cyclophosphamide (Cy), interferon alpha ± steroids (IST), immunomodulatory drugs (IMiDs) and proteasome inhibitors. Comparisons between maintenance groups in the first (post-ASCT) and second line (post-salvage) setting demonstrate no significant differences in progression free survival (PFS) with the exception of IMiDs. These agents, when utilized in the first line maintenance setting, resulted in superior PFS and OS compared to IST (p= 0.0031 and 0.029, respectively) and no maintenance therapy (p= 0.009 and 0.035, respectively). Surprisingly, in the second line maintenance therapy Cy use was associated with a trend favoring improved PFS compared to IMiDs, IFN ± steroids (IST) and bortezomib (Bor) maintenance. Overall survival comparisons demonstrate equivalence between Cy and IST or Bor maintenance groups. Our study confirms advantage of IMiDs as post ASCT maintenance, while the data show that Cy maintenance can be a good alternative in patients who are intolerant or cannot afford IMiDs maintenance, both in first and second line maintenance.
Authors and Affiliations
Michael Byrne, Yunfeng Dai, Jayan Nair, Myron Chang, Jan S. Moreb
Keywords
Related Articles
- EP ID EP342283
- DOI 10.9734/BJPR/2016/27969
- Views 110
- Downloads 0
In vivo and in vitro Toxicity Studies of Crude and Partially Purified Leaf Extracts of Jatropha curcas in Wistar Albino Rats
Aims: Jatropha curcas (J. curcas) is a plant that has numerous medicinal and industrial applications. Evaluation of in vitro and in vivo acute/sub chronic hepato-renal toxicity of crude methanol J. curcas leaf extract on...
Cytotoxic Effect of Lingzhi Extracts on Gefitinib-resitant Lung Cancer Cells
Aims: The present study was carried out to investigate the cytotoxicity of extracts from Ganoderma and Amauroderma lingzhi species collected in Tay Nguyen, Vietnam. Methods: Mushroom samples were extracted by methanol an...
Clinical Outcome Evaluation of Glycaemic Control in a Metformin-based Therapy of Type 2 Diabetes Mellitus Patients Managed Under Ambulatory Care Settings
Background: Short term clinical outcomes evaluation of glycaemic goals or its control are desirable to monitor response to therapy in individual patients and to identify compliance or other problem areas. Aim and Objecti...
In Vivo Assay of Analgesic Activity of Methanolic and Petroleum Ether Extracts of Manilkara zapota leaves
Aims: The main objective of this work was to observe the analgesic activity of Manilkara zapota (leaves) on mice. Study Design: The Present study was designed to observe pharmacological activities of the crude extracts...
Screening and Production of Peptidase Producing Bacillus Species Isolated from Soil
Aims: Proteases are the most deliberate microbial enzyme at mercantile, industrial, health professional, analytic, symptomatic, outgoing interruption and other sectors. Methodology: About 8 isolates were recovered from...