Post-transplant human cytomegalovirus infection can lead to deterioration and dysfunction of renal allograft tissue
Journal Title: Journal of the Indian Medical Association - Year 2018, Vol 116, Issue 12
Abstract
Human Cytomegalovirus (HCMV) infection could lead to a renal allograft failure in post-transplant recipients even after a successful histocompatibility match and absence of donor specific preexisting antibody. The tentative possibilities lead to the theory of molecular mimicry as HCMV showed a sequence homology to the ß chain of human histocompatibility complex HLA DR. Therefore, viral peptide could induce antibodies that specifically recognized by human DR ß chain.Thus a regular posttransplant monitoring of HCMV and proper therapeutic intervention is highly warranted in case of renal allograft recipients. Moreover, CMV infection may precipitate acute rejection. Most transplant programs, use routine anti CMV prophylaxis 100 to 200 days
Authors and Affiliations
Arpita Ghosh Mitra, Nasifa Hasan, Soma Choudhury, Saheli Podder, Ankita Das, Sudip Roy, Nikhilesh Raychaudhuri, Dilip Kumar Pahari
Keywords
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- EP ID EP619449
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