POTENTIAL IMPACT OF COQ10 AND VITAMIN E AGAINST (STZ) INDUCED METABOLIC DETERIORATION IN THE ALBINO RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: This study evaluates the hypoglycemic effect of COQ10 and Vitamin E are determined using STZ induced diabetic rats.Methods: Rats selected for this study were divided into five groups of ten rats each as follows: first group Normal control rats, the second is considered as diabetic groups, injected intraperitoneal with a single dose of STZ (60 mg/kg B. wt). the third group Diabetic rats orally administered glibenclamide drug 10 mg/kg B. wt daily for 30 d 4th. And 5th groups were treated orally glibenclamide combined with vitamin E (2% concentration added to the normal basal diet), or coenzyme Q10 at the dose of 10 mg/kg i. p. daily for 30 consecutive days in addition histological examinations of liver, kidney and brain were carried out to confirm the biochemical changes of the diabetic group of rats.Results: All liver enzymes activities alanine and aspartate transferases and alkaline phosphatase (AST, ALT and ALP respectively), kidney function tests; creatinine and total urea, inflammatory biomarkers; CRP, IL-10 and TNF-α. Neurotransmitters; acetylcholine and acetylcholine esterase were enhanced with the highest degree in groups treated with COQ10 or vitamin E in addition to glibenclamide dug, almost restore the normal histological architecture of liver, kidney and brain.Conclusion: Orally supplemented glibenclamide with coenzyme Q10 or vitamin E showing significantly reduced blood glucose levels in STZ induced diabetic rats. It also showed hypolipidemia as well as hepatoprotective effects, enhance histological feature of liver, kidney and brain.Â
Authors and Affiliations
Hanaa H. Ahmed, Hanan F. Aly, Sanaa A. Ali
Keywords
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