PRECLINICAL EVALUATION OF ANTI-DIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF Sterculia foetida LEAVES BY USING WISTAR ALBINO RATS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 6
Abstract
The Anti-diabetic and Antihyperlipidemic activity of the Methanolic extract of the leaves of Sterculia foetida (jangli badam) (family: Sterculiaceae) was investigated on alloxan induced diabetic albino rats. A comparison was made between both plant extract and a known Antidiabetic drug Glibenclamide (10mg/kg). The dried leaves of Sterculia foetida was subjected to extraction by continuous hot extraction method using methanol as a solvent. Phytochemical estimation was done for the presence of phytoconstituents. Dose selection was made on the basis of acute oral toxicity study (100mg/kg, 200mg/kg, and 400mg/kg bodyweight) as per OECD 423 guidelines. Oral administration of extract of Sterculia foetida for 21 days resulted in significant reduction in blood glucose level. The biochemical parameters were analysed. All rats in the diabetic groups had FBG levels well within the diabetic range (>200 mg dL-1) at the initial stage of the experiment but after three weeks of treatment with extracts or Glibenclamide the FBG significantly dropped in dose-dependent manner, and also corrected the lipid profile and liver enzymes. The results suggest that the Methanolic extracts of the leaves of Sterculia foetida (200mg/kg and 400mg/kg) possess significant anti-diabetic and antihyperglycemic activities and restored the metabolic changes in alloxan-induced diabetic rats, but the percentage reduction was higher in Glibenclamide group than in test groups.
Authors and Affiliations
Shazia Hussain S, Janarthan M, Siva Anusha. K, Ranjani. M
Keywords
Related Articles
- EP ID EP33272
- DOI -
- Views 269
- Downloads 0
Study of plant growth regulating antibiotic drugs - 3-(2-benzimidazol)-3-nitro-6- methyl-chromen-4-one with innertransition metal complexes on spinach (spinacia oleracea l.) at different ph
Antibiotic drugs - 3-(2-benzimidazol)-3-nitro-6-methyl chromen-4-one (Chromone derivatives) with inner transition metal complexes at different pH on plant growth of spinach were studied. Plant growth was decided by mea...
Formulation and evaluation of fast dissolving films containing Rizatriptan benzoate
The aim of the present investigation was to develop fast dissolving films of Rizatriptan benzoate using Eudragit EPO, HPMC and PVA. Films of HPMC E5, HPMC E15, PVA and combination of Eudragit EPO and HPMC E5 were prepa...
THE EFFECTS OF AIR POLLUTION ON THE ENVIRONMENT AND HUMAN HEALTH
Pollution is the introduction of contaminants into the natural environment that cause adverse change. Air pollution includes anything introduced by humans into the atmosphere with a damaging effect. The main cause of a...
QUANTITATIVE ANALYSIS OF ACETAMINOPHEN IN NUROMOL TABLETS BY HIGH PRESSURE LIQUID CHROMATOGRAPHY
In this study quantitative analysis of Acetaminophen in Nuromol tablets by High pressure liquid chromatography were reported and discussed. The mobile phase as a mixture of the acetonitrile and water 25:75 v/v, the pH...
A review on biotransformation
Biotransformation means chemical alteration of chemicals such as nutrients, amino acids, toxins, and drugs in the body. It is also needed to render nonpolar compounds polar so that they are not reabsorbed in renal tubu...