Preclinical evaluation of the diabetic wound healing activity of phytoconstituents extracted from Ficus racemosa Linn. leaves
Journal Title: International Journal of Experimental Research and Review - Year 2023, Vol 32, Issue 3
Abstract
Human body has several multi-layered organs, but skin is one of biggest and easiest to access. It serves as body's primary line of defense alongside various skin diseased conditions. Despite receiving sufficient and appropriate care, diabetes wounds heal slowly and may take a week to complete. A progression of connective tissue patch up is the body's natural defense against tissue damage. Fresh leaves of Ficus racemosa were utilized for the study. In this study, two distinct models were employed to compare how well different Ficus racemosa leaf extracts healed wounds. Excision wounds healed more quickly and to a greater extent after being treated with a flavonoid and tannin fraction of Ficus racemosa leaf extract, suggesting improved epithelization. The extract-treated groups also experienced an increase in breaking potency of incision wounds made; higher breaking strength indicates better wound healing. Complete closure of wound of flavonoid fraction and in fraction of Ficus racemosa extract occurred in 16 and 17 days respectively. Standard treatment increased tensile strength in the diabetic linear incision wound model, followed by treatment with the flavonoid fraction and tannin fraction of Ficus racemosa leaves extract. Ultimate finding and outcome of the present study experimentally demonstrates that extracts of the flavonoid and tannin fractions of Ficus racemosa have wound-healing properties and are effective in treating diabetic wounds. From this study, we state that Ficus racemosa flavonoid fraction and tannin fraction extract has a beneficial effect on blood glucose levels, which shows hypoglycaemic activity.
Authors and Affiliations
Sadhana Pawar, Kajal Pawade, Sonali Nipate, Aishawarya Balap, Bhushan Pimple, Vijay Wagh, Ramanlal Kachave, Asmita Gaikwad
Keywords
Related Articles
- EP ID EP720682
- DOI 10.52756/ijerr.2023.v32.032
- Views 48
- Downloads 0
Women Empowerment in India since 1947: A Critical Analysis
The issue of women's empowerment is not new, this is an early concept. To empower the nation, we should empower the women. Discrimination between men and women, domestic violence, lack of education, lack of awareness abo...
Advanced News Archiving System with Machine Learning-Driven Web Scraping and AI-Powered Summarization Using T5, Pegasus, BERT and BART Architectures
Data plays a crucial role in the contemporary era of technology, as it is a vital element in the publication of news on the internet or a website. Nevertheless, understanding long reports in order to fully comprehend eve...
Exploring the Dynamic Nexus between Industrialization, Environmental Pollution and Health Expenditure in Bangladesh: A VECM Approach
Industrialization boosts economic growth but causes pollution, harming public health and raising healthcare costs. Inflation compounds this challenge, as rising prices make healthcare services, both preventive and curati...
Variation in agronomic characters among traditional rice varieties of Cooch Behar, West Bengal: A Case Study
The expertise of agro-morphological variability within a crop and its dispersion across agro-ecological areas may be very useful in managing the crop's germplasm and developing improved methods. Crop failure is guarded a...
Binary and Multi-class Classification of Brain Tumors using MRI Images
A dangerous and potentially fatal condition is a brain tumor. Early detection of this disease is critical for determining the best course of treatment. Tumor detection and classification by human inspection is a time con...