Preclinical Evaluation of the Haematinic Activity of an Oral Indiffusible Mixture of Tamarindus indica L. Leaf Extract
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2019, Vol 16, Issue 1
Abstract
Objectives: Tamarindus indica L. is known to be a multipurpose traditional plant in India. It is used to treat some bacterial infections, parasitic infestations, constipation, and inflammation. It is also used as a blood tonic and for wound healing. This study was designed to substantiate the traditional claim of haematinic activity for T. indica. Materials and Methods: T. indica leaf extract was formulated into an oral indiffusible mixture (TIM) and evaluated for its haematinic activity in phenylhydrazine (single dose of 10 mg/kg per oral for 8 days) induced anaemia. Wistar rats were grouped into six (n=6). Groups I and II served as normal control and disease control groups, respectively. Group III received the standard drug (haematinic suspension 2 mL/kg). Groups IV, V, and VI received the formulated oral indiffusible mixture of T. indica at a dose of 100, 200, and 400 mg/kg, respectively. Results: The TIM was formulated and pharmaceutically optimized. It produced significant increases in red blood cells, hemoglobin, and packed cell volume and a decrease in mean corpuscular volume. Conclusion: The results showed that the treatment with TIM reversed phenylhydrazine induced anemia. However, the short duration of the present study is regarded as a limitation, and therefore a longer duration is required for obtaining better responses.
Authors and Affiliations
Sathiya RAMU, Shwetha Krishna MURTHY, Sukanya KRISHNA, Abhishek Lakkasandra SOMASHEKARAIAH, Vani B. NANDIHALLI, Kanekal Mohammed MUZAMMIL
Keywords
Related Articles
- EP ID EP438024
- DOI 10.4274/tjps.77598
- Views 143
- Downloads 0
Development and Full Validation of a Stability-indicating HPLC Method for the Determination of the Anticancer Drug Temozolomide in Pharmaceutical Form
Objectives: In the present study, an accurate, precise and simple method has been developed for the determination of TMZ in its pharmaceutical form by using HPLC. Materials and Methods: An HPLC method with a DAD was vali...
Study of the Tableting Properties of MCR, a Newly Coprocessed Cellulose-based Direct Compression Excipient
Objectives: In this work, the aim was to coprocess and evaluate a new cellulose-based direct compression tableting excipient (MCR) of improved functionalities by granulation and slugging from locally extracted microcryst...
The Anticancer and Anti-inflammatory Effects of Centaurea solstitialis Extract on Human Cancer Cell Lines
Objectives: Natural products originating from plants have been used for many years in the treatment of various diseases, including cancer. Centaurea solstitialis subsp. solstitialis is used in Turkish folk medicine. This...
Development and in vitro Evaluation of Voriconazole Nanoparticle Formulation for Mucosal Application
Objectives: This study aimed to prepare and evaluate mucoadhesive nanoparticle formulations of voriconazole, an antifungal drug, for mucosal application. It was also aimed to develop and validate a HPLC method of voricon...
Development, Internal and External Validation of Naproxen Sodium Sustained Release Formulation: an Level A In Vitro-In Vivo Correlation
Objectives: The aim of the present study was to develop and validate an in vitro-in vivo correlation (IVIVC) for naproxen sodium-sustained release tablets and to compare their plasma concentrations over time with the imm...