Predicting outcome in primary biliary cirrhosis

Journal Title: Annals of Hepatology - Year 2014, Vol 13, Issue 4

Abstract

Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune liver disease that may ultimately result in liver failure and premature death. Predicting outcome is of key importance in clinical management and an essential requirement for patients counselling and timing of diagnostic and therapeutic interventions. The following factors are associated with progressive disease and worse outcome: young age at diagnosis, male gender, histological presence of cirrhosis, accelerated marked uctopenia in relation to the amount of fibrosis, high serum bilirubin, low serum albumin levels, high serum alkaline phosphatase levels, esophageal varices, hepatocellular carcinoma (HCC) and lack of biochemical response to ursodeoxycholic acid (UDCA). The prognostic significance of symptoms at diagnosis is uncertain. UDCA therapy and liver transplantation have a significant beneficial effect on the outcome of the disease. The Mayo risk score in PBC can be used for estimating individual prognosis. The Newcastle Varices in PBC Score may be a useful clinical tool to predict the risk for development of esophageal varices. Male gender, cirrhosis and non-response to UDCA therapy in particular, are risk factors for development of HCC.

Authors and Affiliations

Willem J. Lammers, Kris V. Kowdley, Henk R. van Buuren

Keywords

Related Articles

Liver involvement in severe humann influenza A H1N1

Influenza A is a disease caused by a RNA virus, member of the orthomyxoviridae family. The influenza infection is characterized primarily by pulmonary affection that may advance to an acute pulmonary respiratory failure...

Distribution of HCV genotypes and HCV RNA viral load in different regions of Mexico

Background and aim. To identify the geographic distribution of hepatitis C virus (HCV) genotypes and HCV RNA viral load in a large number of HCV-infected carriers in Mexico. Methods. Patients with chronic hepatitis C (n...

Is ursodeoxycholic acid detrimental in obstructive cholestasis? A propos of a case of malignant biliary obstruction

Ursodeoxycholic acid (UDCA) is the first choice medication for most cholestatic hepatopathies, due to its capability to counteract inflammation and bile-acid-induced liver damage, two common features in cholestasis. How...

Acute phase proteins for the diagnosis of bacterial infection and prediction of mortality in acute complications of cirrhosis

Introduction. Bacterial infection is a frequent complication in patients with decompensated liver cirrhosis and is related to high mortality rates during follow-up of these individuals. We sought to evaluate the diagnost...

Download PDF file
  • EP ID EP78409
  • DOI -
  • Views 132
  • Downloads 0

How To Cite

Willem J. Lammers, Kris V. Kowdley, Henk R. van Buuren (2014). Predicting outcome in primary biliary cirrhosis. Annals of Hepatology, 13(4), 316-326. https://www.europub.co.uk/articles/-A-78409