PREDICTION OF NOVEL ANTI-EBOLA VIRUS COMPOUNDS UTILIZING ARTIFICIAL NEURAL NETWORK (ANN)
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 7
Abstract
Artificial Neural Network (ANN) analysis is shown to predict the molecular properties of new anti-EBOLA compounds following training/learning by use of 60 previously known and studied drugs. Following training/learning by applying properties of 60 known drugs the TIBERIUS ANN system can efficiently predict the molecular properties of comparable new drugs. Molecular weight (MW) is an important and dominant property of perspective drugs considered for clinical trials. TIBERIUS ANN was able to predict comparable values of MW for drugs following training cycles. One-way ANOVA, F and T tests indicate that actual and predicted MW have the same means (P=.99). Passing-Bablok regression showed that ANN predicted MW are comparable to actual MW. The coefficient of variation indicated actually less variation in predicted MW as opposed to actual MW. A plot of actual MW values versus ANN predicted MW values, produced a line having no departure from linearity (P=.82), and a 95% ellipses having 55 drugs therein. TIBERIUS ANN allows investigators to input separate property values to predict suitable outcome based on the 60 known drugs. ANN prediction of pharmaceutical properties of new drugs is shown to be efficient and accurate when based on a known set of drugs for training/learning cycle.
Authors and Affiliations
Dr. Ronald Bartzatt
Keywords
Related Articles
- EP ID EP622631
- DOI -
- Views 127
- Downloads 0
COMPARATIVE EFFECT OF VITAMINS A AND E ON SPERM MORPHOLOGY OF NICOTINE-TREATED WISTAR RATS
This study compared the effect of vitamins A and E on sperm morphology of nicotine-treated rats. Thirty male wistar rats were randomly assigned into six groups (n=5) thus: control received 0.2mL/kg of normal saline; Nico...
IN VITRO ANTIBACTERIAL ACTIVITES, SAFETY STUDIES AND PHYTOCHEMICAL SCREENING OF DREGEA SCHIMPERI CLARK (ASCLEPIADACEAE) EXTRACTS
Plants synthesize phytochemical compounds for protection against environmental stress and diseases. Some of the phytochemicals are used for curative and preventive medicine. Over 90% plant materials are used in tradition...
A REVIEW ON AROMA PROFILE OF CINNAMOMUM SPECIES IN NORTH AND NORTH EAST INDIA
Cinnamomum genus belonging to the family Lauraceace comprises of evergreen trees and shrubs. Over 250 species of Cinnamomum have been reported all over the world which are distributed in tropical and subtropical regions...
RISK FACTORS FOR OBESITY IN FEMALE COLLEGE STUDENTS IN UNIVERSITY OF HAIL, SAUDI ARABIA
Background: Because of the increasing obesity rates in populations, population specific causes need to be identified. The present study aimed at determining the contribution of parental socioeconomic variable and life st...
PHARMACEUTICAL CARE IMPLEMENTATION: PHYSICIANS’ KNOWLEDGE, AWARENESS, ATTITUDE, AND PRACTICE STUDY, GEZIRA STATE, SUDAN
Pharmaceutical care, basically targets improvement of patients‘ therapeutic outcomes and quality of life. This study aimed to explore physicians‘ awareness, attitude, knowledge and practice of pharmaceutical care impleme...