Prediction of Significant Neonatal Jaundice by Cord Blood Albumin at Birth in Neonates with completed 35 weeks of gestation
Journal Title: Journal of Chalmeda AnandRao Institute of Medical Sciences - Year 2017, Vol 13, Issue 1
Abstract
Background and Aim: Over two third of newborn babies develop clinical jaundice. Bilirubin induced brain damage depends on free bilirubin as evidenced by mass action equation. Our study aims was to estimating the prediction of newborns at risk of developing significant neonatal jaundice early at birth, by cord blood albumin levels, and to plan follow-up programme effectively, to guide the parents, to prevent bilirubin induced neurologic damage. Materials and Methods: This is an institutional cross sectional study. Two samples are collected from each subject, one from cord at birth and other at 72 hours of life for bilirubin level. Study was doneover one year including all the sequentially born neonates after completion of 35 weeks of gestation.The sample of 166 was divided into 2 groups, A and B according to cord blood albumin levels less than or equal to 3.336 gm/dL , or >3.336 gm/dL respectively and then followed till discharge. Wherever necessary further laboratory tests were done and managed accordingly. Results: Newborns in Group Aand B are 86 (51.80%), and 80(48.19%)respectively. In group A, 76 (88.37%) neonates developed jaundice, of which 10 (13.15%) required phototherapy, whereas 78 (97.5%) neonates in group B developed jaundice, of which 6 (7.69%) needed phototherapy. Conclusion: When 3.336 gm/dL of cord blood albumin is taken as cut off, to predict neonatal jaundice at birth, it is clear from data that those with <3.336gm/dLcord albumin are at increased risk of developing significant jaundice requiring photo therapy when compared with >3.336 gm/dL. So we conclude that cord serum albumin levels may correlate the severity of neonatal jaundice.
Authors and Affiliations
Sudhakar Chiluka, Srinivas Madoori, Subhan Basha, Praneet Reddy
Keywords
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