Predictive Significance of Interleukin-6, Interleukin-8 and Tumor Necrosis Factor-Alpha in Paroxysmal Atrial Fibrillation
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 8
Abstract
Our previous studies presented significant increases in plasma concentrations of Interleukin-6 (IL-6), Interleukin-8 (IL-8) and Tumor Necrosis Factor-alpha (TNF-α) as early as before the twenty-fourth hour after the clinical manifestation of paroxysmal atrial fibrillation (PAF). The early changes in pro-inflammatory cytokines give serious reasons to suppose that inflammatory process participates directly in the disease initiating mechanisms. In this sense, it is quite appropriate to seek in these changes a predictive value for PAF manifestation. IL-6, IL-8 and TNF-α were studied in 51 patients (26 men, 25 women; mean age 59.84±1.60 years) with PAF (time of the occurrence<48 hours) and 52 controls (26 men, 26 women; mean age 59.50±1.46 years) matched by gender, age and comorbidities. In the present study we used a logistic regression model with a single explanatory variable and a multivariable logistic model to determine the prognostic value of the indicators. The logistic regression model with a single explanatory variable showed that IL-6, IL-8 and TNF-α were statistically significant indicators of the clinical manifestations of PAF (p<0.001; p=0.045; p=0.014, respectively). With the increase in their values, the probability of developing the disease also increased(Bi=0.33 >0; Bi=0.34 >0; Bi=0.44 >0, respectively). The multivariate logistic model confirmed the results (p=0.017; p=0.049; p=0.012, respectively). Plasma concentrations of IL-6, IL-8 and TNF-α provide prognostic information about the clinical manifestation of PAF. They could be used in the overall clinical risk assessment, which in turn would affect the prophylactic and therapeutic approach to the disease. Keywords: Interleukin-6 (IL-6), Interleukin-8 (IL-8), Tumor Necrosis Factor-alpha (TNF-α), paroxysmal atrial fibrillation
Authors and Affiliations
Mariya Negreva, Krasimira Prodanova, Svetoslav Georgiev
Keywords
Related Articles
- EP ID EP374413
- DOI -
- Views 87
- Downloads 0
Clinical, Laboratory, Radiological & Autopsy Correlation In Brain Tuberculosis
Abstract: Tuberculosis is a major health problem in developing countries. A significant number of patients admitted to the hospitals in our country succumb to tuberculosis of the brain. Central nervous system tuberculosi...
Review of Supraglottic Airway Devices (SAD)
Abstract: The development of the laryngeal mask airway in 1981 was the first step toward widespread use and acceptance of the supraglottik airway device (SGAD). SGAD have revolutionized the field of airway management. Th...
Mermaid Syndrome (Sirenomelia): With Use of Mifepristone and Misoprostol in Early First Trimester with Failed Medical Abortion and Continuing Pregnancy in A Multipara with Bad Obstetric History
Mermaid syndrome (Sirenomelia) is a congenital structural anomaly characterized by an abnormal development of the caudal region of the body with different degrees of fusion of the lower extremities giving them the appear...
Effect of Ethanolic Extract of Tinosporacordifolia on Behavioral Alterations Induced By Long Term Cerebral Hypoperfusion in Rats
Abstract:Cognitive deficit which represent many neuropsychiatric conditions and/or alone as developmental factor for the demand use of nootropic agent to enhance cognitive functions. In current scenario, there is tremend...
Assistant Professor, Department of Ophthalmology, KIMS and PBMH, Bhubaneswar, Orissa
Abstract:Uveitis is a leading cause of ocular morbidity, most cases being idiopathic. The advent of steroid therapy has brought about drastic reduction in the incidence of ocular complications of uveitis....