PREDICTORS OF PROGRESSION OF CHRONIC PYELONEPHRITIS IN CHILDREN
Journal Title: УКРАЇНСЬКИЙ ЖУРНАЛ НЕФРОЛОГІЇ ТА ДІАЛІЗУ - Year 2016, Vol 4, Issue 52
Abstract
Introduction The search for new diagnostic capabilities adverse forecasting of chronic pyelonephritis in children is a pressing issue today. To determine the degree of destruction of renal parenchyma, structural and functional changes in kidney informative study of fermenturiyi, analyze its relationship with albuminuria and profibrozuyuchymy growth factors. The aim was to identify predictors of progression of chronic pyelonephritis in children to assess the level of kidney function in dynamic observation. Materials and Methods: Pediatric Nephrology at the Department of SI «Institute of Nephrology AMS of Ukraine» at the CST №7 of Kyiv was examined 191 child over 5 years in age from 3 to 17 years. Results: In the group of children with progressive chronic pyelonephritis relapsing course 2fi-MG urine compared with groups of 2fi-MG there PNhighest level of reliable patients who had not frequent relapses and recovered (p <0.001). To determine infringement tubular renal function, analyzed the $2-MG urine and serum levels with enzyme activity NAG, NAG B and in patients with chronic pyelonephritis and established significant coefficients of paired correlation 2fi-MG serum and urine $2-MG between levels and activity Nag, NagB in urine. Discovered reliable positive correlation between levels of albuminuria and TGF-fi, which is profibrotychnym factor (r = 0,48, p <0.001) and identified a significant increase in its levels in patients with chronic pyelonephritis. Conducted stepwise multiple linear regression analysis revealed a reliable connection between the measure glomerular filtration rate decline per year (which is determined by progression) and $2-MG levels of blood TGF-^, $2-MG in urine, albuminuria and indicators renoscintigraphy - ENPstand% inclusion RFP180 min. Conclusions. Predictors of progression of pyelonephritis in children are: increased activity of lysosomal enzymes, maintaining elevated levels $2-MG serum and urine regardless of the degree of inflammatory activity in the kidneys and albuminuria
Authors and Affiliations
O. Lavrenchuk, I. V. Bagdasarova, V. E. Driyanska, L. V. Korol, G. D. Suslova
Keywords
Related Articles
- EP ID EP354006
- DOI 10.31450/ukrjnd.4(52).2016.05
- Views 93
- Downloads 0
DISTURBANCES OF NUTRINIONAL STATUS IN PATIENTS TREATED BY PERITONEAL DIALYSIS
this work is devoted to the problem of malnutrition in patients who are treated by peritoneal dialysis, the main causes of violations of nutritional status were observed, and also the classification of protein-energy mal...
Зв’язок фактора росту фібробластів 23 та ліпідного обміну у хворих на хронічну хворобу нирок
Сучасні наукові дослідження демонструють вплив фактору росту фібробластів 23(ФРФ-23) на об’єм та розподіл жиру в організмі. Метою роботи було вивчити ліпідний обмін у хворих із хронічною хворобою нирок (ХХН) шляхом оцінк...
PATHOMORPHOLOGICAL CHANGES IN RENAL PARENCHYMA, AFTER MODELING OF ACUTE PYELONEPHRITIS IN MICE, DEPENDING ON THE ABILITY OF BACTERIA TO FORM BIOFILMS
Urinary tract infection is one of the most common infectious diseases that affects people of any age and sex. The purpose of our study was to determine morphological changes in acute pyelonephritis, depending on the abil...
DYSLIPIDEMIA AS A FACTOR FOR PROGRESSION OF RENAL OSTEODYSTROPHY AND CORONARY HEART DISEASE IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON PERITONEAL DIALYSIS
Numerous studies of the last years focused on various links of pathogenesis and factors for progression of coronary heart disease (CHD) and chronic kidney disease (CKD) allowed to find intersection, such as progression o...
VASCULAR ACCESS OPTIONS AT HEMODIALYSIS THERAPY INITIATION: COMPLICATIONS AND SURVIVAL OF PATIENTS WITH CHRONIC KIDNEY DISEAS STAGE 5 D
The annual increasing of dialysis population results tofocus world attention on the problems associated with improving of survival among patients with chronic kidney disease stage VD (CKD VD st.)., decreasing iatrogenic...