Preliminary phytochemical screening and cytotoxic potentials from leaves of Sanchezia speciosa Hook.f
Journal Title: International Journal of Advances in Scientific Research - Year 2015, Vol 1, Issue 3
Abstract
Background: Sanchezia speciosa Hook.f is an important medicinal plant with several ethnomedicinal properties. In the present experiment the leaves of this plant were screened for the presence of major phytochemical groups. The phytochemicals are the wide variety of compounds produced by plants manipulated widely in the pharmacognostic drug development and in the treatment of the major ailments. Methods: Phytochemical screenings were performed by various functional group tests. All the leaves extracts were subjected to brine shrimp lethality bioassay and standard anticancer drug vincristine sulphate was used as positive control. Results: Phytochemical investigation of the leaves extracts showed the presence of alkaloids, glycosides, flavonoids, triterpenoids, carbohydrates, steroids, phenolic compounds, saponins and tannins. The ethyl acetate fractionates of the leaves extracts were positive for all the phytochemicals tested while n-hexane fractionates were negative for flavonoids and phenolic compounds. The n-hexane and ethyl acetate soluble fractionates showed significant cytotoxic activities with median lethal concentrations (LC50) 19.95 µg/mL and 12.88µg/mL while LC50 for the vincristine sulphate was 10.96 µg/mL. Conclusion: This study shows that the leaves of Sanchezia speciosa Hook. f may have potentials in control of carcinogenesis in the field of pharmacology.
Authors and Affiliations
Shumaia Parvin, Md. Abu Shuaib Rafshanjani, Md. Abdul Kader, Tahmida Sharmin
Keywords
Related Articles
- EP ID EP327864
- DOI 10.7439/ijasr.v1i3.1842
- Views 145
- Downloads 0
Formulation and Evaluation of Lecithin Organogel for Treatment of Arthritis
Arthritis is a disease of the joint that involves inflammation of one or more joints. The common symptoms of arthritis disorders include varied levels of pain, swelling, joint stiffness, and sometimes a constant ache aro...
Study on the efficiency of continuous flow-based constructed wetland system for grey water treatment
Water is inevitable for our life. Due to the population growth, there is a tremendous pressure on the existing fresh water resources such as surface water and ground water. Increasing water demand and improper usage of p...
Estimation of Ciprofloxacin Hydrochloride in Bulk and Formulation by Derivative UV-Spectrophotometric Methods
Simple, fast and reliable spectrophotometric methods were developed for determination of Ciprofloxacin Hydrochloride in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Dist...
In silico analysis of fluoride transport proteins from prokaryotic and eukaryotic organisms
In silico analysis of Fluoride transporter proteins obtained from database are presented in this study. The composition of alanine and glycine was high while low concentrations of aspartic acid, cysteine and glutamine we...
Evaluation of the effectiveness of selected intervention in reducing level of pain perception and birth experience among primi gravida mothers
Aim: To evaluate the effectiveness of birth bal therapy in terms of level of pain perception and birth experience among primi gravida mothers. Participants and setting: The study was conducted in Nirmala Hospital, in Sur...