PREPARATION AND CHARACTERIZATION OF FREEZE DRIED CRYSTALS OF IBUPROFEN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12
Abstract
Ibuprofen, an anti-inflammatory drug, exhibits poor water solubility and flow properties.. Crystallization medium used for freeze dried crystals of Ibuprofen consisted of Isopropyl alcohol and water (50:50%) respectively. Freeze dried crystals were characterized by differential scanning calorimetry, Infrared spectroscopy, X-ray diffractometry and scanning electron microscopy. Micromeritic and mechanical property and dissolution behavior studies were carried out. Process variables such as amount of bridging liquid, stirring time and duration of stirring were optimized. Dissolution profile of the freeze dried crystals was compared with pure sample and recrystallized sample. Freeze dried crystals exhibited decreased crystallinity and improved micromeritic properties. The dissolution of the freeze dried crystals was improved compared with pure sample.
Authors and Affiliations
Mudit Dixit , Parthasarathi Kulkarni , Selvam Panner , Mohsin Syed
Keywords
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