Preparation and evaluation of methyl salicylate counter- Irritant emulgel of mefenamic acid
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2013, Vol 1, Issue 1
Abstract
Topical delivery of hydrophobic drug with good patient acceptance is a big challenge which is successfully handled by Emulgels. The objective of the study was to prepare emulgel of mefenamic acid, a NSAID, using Carbopol 934P as a gelling agent and methyl salicylates as counter irritant agent. Theemulsion was prepared and it was incorporated in gel base in the ratio of 1:1. The prepared six formulations were evaluated for rheological studies, spreading coefficient studies, bioadhesion strength, in vitro release and ex vivo release studies. From the obtained results it can be concluded that topical emulgel of Mefenamic acid possess great suitability for topical delivery.
Authors and Affiliations
Vivek P. Chavda, Jitendra Patel, Kaushik Parmar, Sanjay Nakum, Moinuddin M. Soniwala, Jayant R. Chavda
Keywords
Related Articles
- EP ID EP31448
- DOI -
- Views 517
- Downloads 3
Formulation of Gymnema Sylvestre mix Incorporated Foods for Diabetes Mellitus
Diabetes is defined as a group of metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secreti...
A Review on current scenario of Pharmacosomes
Limited permeation into the cells and the adverse effects are the major detriments with most of the drugs used in the chronic disorders. So from the past few decades our focus is on the advanced drug delivery system whic...
A rare case of xanthogranulomatous cholecystitis mimicking gall bladder carcinoma
Xanthogranulomatous cholecystitis is an unusual form of benign chronic cholecystitis with focal or diffuse destructive inflammatory process characterized by thickened fibrotic disrupted gall bladder wall with foamy hist...
Polymeric systems as controlled release drug products: A review
The use of various new techniques and therapeutic systems to obtain a controlled drug release in microbial infections is a more and more exploited approach in the modern pharmaceutical technology. Growing interest in thi...
Microemulsions: A potential novel drug delivery system
Microemulsions are defined as clear, transparent, thermodynamically stable, isotropic mixtures of oil and water, frequently in combination with a co-surfactant. Recently microemulsion formulations are widely used for t...