PREPARATION AND EVALUATION OF TIMOLOL MALEATE MUCOADHESIVE BUCCAL TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
The present investigation was concerned with preparation and evaluation of mucoadhesive buccal tablets containing antihypertensive drug, Timolol maleate to circumvent the first pass effect and to improve its bioavailability with reduction in dosing frequency and dose related side effects. The tablets were prepared by direct compression method. Eight formulations were developed with varying concentrations of polymers like chitosan, hydroxyethylcellulose and hydroxypropylmethylcellulose. The formulated tablets were evaluated for weight variation, hardness, surface pH, drug content uniformity, swelling index, bioadhesive strength and in vitro drug dissolution study. FTIR studies showed no evidence on interactions between drug, polymers and excipients. The in vitro release of Timolol maleate was performed under sink conditions (Phosphate buffer pH 6.8, 37±0.5ºC, 50rpm) using USP-XXIV dissolution apparatus type II. The best in vitro drug release profile was achieved with the formulation F5 which contains the drug, chitosan and HPMC K4M in the ratio of 1:2.5:10. The surface pH, bioadhesive strength and swelling index of formulation F5 was found to be 6.34, 36.50g and 80%, respectively. The formulation F5, containing 10 mg of Timolol maleate exhibited 7 hrs sustained drug release i.e. 98.18% with desired therapeutic concentration. The in vitro release kinetics studies of optimized formulation reveal that follows zero order kinetics.
Authors and Affiliations
Senthil Adimoolam , Pratik Chauhan , Jismon Jose, MM Mahin , Yakinkumar Siroya
Keywords
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