Preparation, Characterization and In Vitro Drug Release Studies of 6-mercaptopurine Thin Film
Journal Title: STAR Journal - Year 2014, Vol 3, Issue 2
Abstract
Oral thin films of 6-mercaptopurine were fabricated from mucoadhesive polymer, chitosan and polyvinylpyrrolidone for the purpose of prolonging drug release and improving its bioavailability. All fabricated film formulations prepared were smooth and translucent, with good flexibility. The weight and thickness of all the formulations were found to be uniform. These films were also evaluated for surface pH, folding endurance, swelling percentage (% S) and in vitro disintegration time. Scanning Electron Microscopy (SEM) and Fourier Transform Infrared (FTIR) were used to evaluate the physico-chemical nature of the films. In-vitro drug release have shown enhanced release profiles for thin films compared to pure drug and the release patterns have been found to be pH dependant. The results of the study reveals that fabrication of 6-MP oral thin film by using solvent cast technology is a simple and an efficient method for drug delivery to achieve desired therapeutic compliance.
Authors and Affiliations
Prem Kumar G| Department of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore, Karnataka, India, Jagadeesh S. Sanganal| Department of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore, Karnataka, India, Manohara C| Department of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore, Karnataka, India, Swamy KB| Department of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore, Karnataka, India, Aparna V| Department of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore, Karnataka, India, Shridhar NB| Department of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore, Karnataka, India, Narayana Swamy HD| Department of Veterinary Pathology, Veterinary College, Bangalore, Karnataka, India, Ramachandra SG| Central Animal Facility, Indian Institute of Science, Bangalore, Karnataka, India, Phani AR| Nano-RAM Technologies, Bangalore, Karnataka, India
Keywords
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