Prescription pattern and adverse drug reaction profile of drugs prescribed with focus on NSAIDs for orthopedic indications at a tertiary care hospital
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2016, Vol 3, Issue 4
Abstract
Introduction: The Non-steroidal Anti-inflammatory Drugs (NSAIDs) constitute the largest group of drugs used worldwide for indications like rheumatoid arthritis, osteoarthritis, low back pain etc. Periodic evaluation of drug utilization patterns enable suitable modifications in prescription of drugs to increase the therapeutic benefit and decrease adverse effects. Objective: To analyze the prescription patterns and adverse drug reaction profile of NSAIDs prescribed in orthopedic outpatient department of Tertiary Care Hospital. Study design: observational, cross-sectional study. Results: 360 patients enrolled. Average number of drugs per prescription was 3.83. Total 1382 drugs were prescribed, out of which 418 were NSAIDs (30.24%). Ibuprofen was most commonly prescribed agent (62.79%), followed by Diclofenac (40.66%). Ibuprofen was found to be the commonest drug associated with ADRs. Conclusion: Ibuprofen was most commonly prescribed NSAID and also responsible for majority ADR. There was higher prevalence of irrational prescribing, polypharmacy and under reporting of ADR.
Authors and Affiliations
V. M. Motgahre, C. S. Bajait, A. Turankar, S. A. Pimpalkhute, M. Dholpure
Keywords
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