PREVALENCE AND FUNGAL PROFILE OF PULMONARY ASPERGILLOSIS IN IMMUNOCOMPROMISED AND IMMUNOCOMPETENT PATIENTS OF A TERTIARY CARE HOSPITAL
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2014, Vol 3, Issue 1
Abstract
Background: Aspergillus is a fungus which may present an array of pulmonary manifestations, depending on the patient's immunological and physiological state. Although the incidence of pulmonary aspergillosis occurs primarily in immunocompromised patients but the incidence is also rising in immunocompetent individuals, especially in developing countries. Aim: The objective of the study was to determine the prevalence and predisposing factors of pulmonary aspergillosis along with species identification. Materials and Methods: One hundred and three patients admitted to the Department of Chest and Tuberculosis and in the Department of Medicine from Jan 2012 to Jan 2013 were included in this study. The patients were epitomized on the basis of clinical signs and symptoms, physical examination, chest radiography, CT scans, histopathological examination, bronchoscopy and fungal examination including potassium hydroxide mount, fungal culture of sputum and bronchoalveolar lavage. Species identification was done by colony characteristics, slide culture and Lactophenol Cotton blue mount. Results: Out of the 103 patients, (63 males and 40 females) Aspergillus species has been isolated from 17 (16.5%) males and 07 (6.79%) females. Various predisposing factors of pulmonary aspergillosis have been identified in which pulmonary tuberculosis, chronic smoking and environmental exposure to asbestos, cement its tops the list. Many of the patients had multiple predisposing factors. Aspergillus species were isolated in 24 (23.3%) cases. Aspergillus fumigatus was the predominant species isolated in 13 (54.16%) cases followed by Aspergillus flavus in 07 (29.16%) cases, Aspergillus niger in 03 (12.5 %) and Aspergillus terrus in 1 (4.16%) cases. Conclusion: It is concluded that the prevalence of pulmonary Aspergillosis is quite high in immunocompromised individuals and low in immunocompetent individuals. An adequate and efficient evaluation of the etiological agents has a crucial role in the management of such patients.
Authors and Affiliations
Prakash Ved| Associate Professor, Department of Microbiology, RMCH, Bareilly, UP, India, Mishra Prem P| Assistant Professor, Department of Microbiology, RMCH, Bareilly, UP, Indiaو Corresponding author email: prem6284@gmail.com, Verma Shashi K| Professor, Department of Physiology, RMCH, Bareilly, UP, India, Sinha Shivani| MD student Department of Microbiology, RMCH, Bareilly, UP, India, Sharma Mahendra| Statistician cum lecturer, Dept of community Medicine; RMCH, Bareilly, UP, India
Keywords
Related Articles
- EP ID EP11109
- DOI -
- Views 330
- Downloads 17
The possible role of oxidants and antioxidant imbalance in pathophysiology of Schizophrenia
Background: Employment of low dose combinations of two antihypertensives, with different mode of action has gained acceptance worldwide for the treatment of mild to moderate hypertension. However, most studies in hyperte...
Evaluating the efficacy of Regulated 12-Session Matrix Model in reducing susceptibility in methamphetamine-dependent individuals
Methamphetamine (ab)use have gained popularity among youth and is increasingly become a part of mainstream culture. Methamphetamine(ab)use is dangerous because of its wide range adverse outcomes and hazardous sustainin...
Comparing the Effect of Simulation and Video-based Education on Mothers’ Self-Efficacy in Bathing Preterm Infants
Self-efficacy is the belief of person about his or her ability and capacity to accomplish a task or to deal with the challenges of life. Since, Self-efficacy is an important factor for mothers who are caring their child...
The influence of biochanin a consumption on c-CBL-associated protein level in adipose tissue of streptozotocine-nicotinamide induced diabetic rats
Increased c-Cbl associated protein (CAP) level in adipose tissue can facilitate glucose uptake via GLUT 4 in adipocytes. Increased level of CAP results from activation of PPARγ transcription factor. Biochanin A, soy i...
EFFECTS OF PROTEIN ENERGY MALNUTRITION ON PERIPHERAL NERVE CONDUCTION IN CHILDREN
Background: Peripheral nerve conduction changes caused by malnutrition can be shown clinically and electrophysiologically. They are produced mainly due to deficiency of micro and macronutrients like vitamins, minerals...