Prevalence of Beta Thalassemia and Other Hemoglobino-pathies - Carriers Status of Students in Educational Institutes of Central Punjab
Journal Title: Journal of Fatima Jinnah Medical University Lahore - Year 2017, Vol 11, Issue 4
Abstract
Background: Hemoglobinopathies are a group of genetic disorders characterized by abnormalities in qualitative or quantitative production of haemoglobin (Hb). Beta thalassemia is the most common inherited blood disorder found in Pakistan, other less common are Hb E, Hb D-Punjab and Hb S. This study is part of awareness campaigns carried out among school and college students to educate them regarding these diseases especially beta thalassemia, its inheritance pattern and various prevention tools available. Subjects and Methods: Awareness about the disease, its complications, treatment and prevention were given to the students. Free, voluntary carrier screening was done by collecting 3 ml of EDTA blood for complete blood count (CBC) and haemoglobin electrophoresis/HPLC. Genetic counselling and extended family screening was offered to students at risk. Results: A total of 3057 students were screened during the study period. About 77 were found to be carriers of beta thalassemia, 12 of HbD, 7 of HbE, and 1 was compound heterozygous for HbE and beta thalassemia. The collective prevalence of carriers was 3.1%. Conclusion: Awareness seminars help to provide information about the disease and its prevention. The collected data about the prevalence and distribution is helpful in devising prevention strategies to help affected individual to make informed choices.
Authors and Affiliations
SHABNAM BASHIR, YASMEEN EHSAN, HUSSAIN JAFRI
Keywords
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