PREVALENCE OF HELICOBACTER PYLORI INFECTION IN GASTRIC CANCER IN PATIENTS ATTENDING A TERTIARY REFERRAL UNIT: A CROSS SECTIONAL STUDY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 22
Abstract
BACKGROUND The prevalence of gastric cancer is associated with several factors including geographical location, diet, and genetic background of the host. Helicobacter pylori infection is an important etiological factor for the occurrence of non-cardiac gastric adenocarcinoma in developing and underdeveloped countries with poor hygienic conditions. There are no documented studies on the association of gastric carcinoma with H. pylori from the mid Kerala districts of Palakkad, Thrissur and Malappuram. These districts have got the highest incidence in Kerala for carcinoma stomach and Government Medical College, Thrissur is the primary referral institution for such cases. METHODS A prospective cross-sectional study was conducted at General Surgery department of a tertiary care hospital of Kerala. Patients suspected to have carcinoma stomach undergoing endoscopy/open surgery, who have consented to take part in the study were tested for H. pylori infection. RESULTS Distribution of gastric adenocarcinoma and the prevalence of H. pylori, we found that H pylori was present in 29 cases of total 66 cases Prevalence of H. pylori is 43.9% among gastric carcinoma patients in this study. CONCLUSIONS Even though many advances in the understanding of gastric cancer have been made, the disease is still one of the malignancies with the highest incidence and mortality rates worldwide. It is believed that there is an overall decline in gastric cancers due to reduction and eradication of H. pylori infection with improved sanitation. Once carcinoma is detected, H. pylori is not given much significance. It is important to fully understand the inflammatory response initiated by the infection in order to fully block the cascade of events that lead to gastric cancer.
Authors and Affiliations
Santhosh P. V, Ravindran Chirukandath, Geethanjali M. , Vinodh M.
Keywords
Related Articles
- EP ID EP667291
- DOI 10.18410/jebmh/2019/321
- Views 88
- Downloads 0
ENTEROHEPATIC FISTULA ASSOCIATED WITH LIVER ABSCESS - AN EXTREMELY RARE PRESENTATION
Gastrointestinal (GI) fistulas represent abnormal duct like communications between the gut and another epithelial-lined surface, such as another organ system, the skin surface, or elsewhere along the GI tract itself.(1)...
HEPATOBILIARY ASCARIASIS: 2 CASE REPORT
Hepatobiliary ascariasis is a relatively uncommon helminthic disease occasionally found in Indian subcontinent and third world country. They commonly present as right hypochondrial pain with mild jaundice. Vomiting may a...
AN OBSERVATIVE STUDY OF COMPARISON OF EFFICACY AND TOLERABILITY BETWEEN LOSARTAN AND COMBINATION OF LOSARTAN AND AMLODIPINE IN THE MAINTENANCE THERAPY OF HYPERTENSION IN OPD OF GENERAL MEDICINE DEPARTMENT AT GIMS, KALABURAGI
BACKGROUND Hypertension is the most common cardiovascular disease. The prevalence of hypertension increases with advancing age. The beta receptor antagonists provide effective therapy for all grades of hypertension. Comp...
HAEMATOLOGICAL PROFILE IN RADIOGRAPHERS EXPOSED TO LOW DOSE RADIATION
BACKGROUND The cells of the haematopoietic system are highly radiosensitive and the medical radiographers who are exposed to chronic ionizing radiation are more prone to get haematological disorders later in life. A chan...
PROCALCITONIN AS A DIAGNOSTIC MARKER OF NEONATAL SEPSIS
Neonatal sepsis is difficult to diagnose because it is associated with nonspecific signs and symptoms and a high index of suspicion is required for early diagnosis. Several acute phase reactants help to indicate the pres...