PREVALENCE OF HEPATITIS B AND CARRIER RATE IN GENERAL POPULATION AT A TERTIARY CARE HOSPITAL

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PREVALENCE OF HEPATITIS B AND CARRIER RATE IN GENERAL POPULATION AT A TERTIARY CARE HOSPITAL

Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 3

Abstract

BACKGROUND Hepatitis B is a disease that has been gaining more and more interest of late with a lot of research being conducted on its pathogenicity, its structure, the epidemiology of the disease and prospects and outcomes of vaccination. It has captured so much attention because of its grievous consequences and widespread prevalence as well as the ease with which it can be controlled. Our objective was to assess trends in the prevalence of hepatitis B virus (HBV) infection in a tertiary care hospital in Bangalore and to determine the HBV carrier rate, magnitude and pattern of HBV infected super carriers and simple carriers in patients positive for hepatitis B surface antigen. MATERIALS AND METHODS This is a hospital-based prospective observational study. The prevalence of HBV infection was determined in a representative sample of the general population. It was a hospital-based prospective study. Study period being 2 months, June - August 2015 with sample size of 2061 samples. Inclusion Criteria: Samples taken randomly during inpatient routine screening, outpatient screening or blood bank donor screening. Exclusion Criteria: Subjects suffering from present liver disease or HIV positive at point of blood collection. RESULTS The total number of samples tested for HBsAg by the chemiluminescence method was 2061, out of which 29 samples were found to be HBsAg carriers satisfying the inclusion and exclusion criteria. This gives the gross rate of positivity as [29/2061] * 100= 1.41%. The studies on prevalence HBV 2 out of the 29 HBsAg positive individuals tested positive for HBeAg, giving a percentage of 6.89%. This indicates a state of active HBV DNA synthesis and high infectivity (Super carrier). CONCLUSION HBsAg have given results which are consistent in their inconsistency, but that is probably due to the vast and diverse nature of populations across India. However, we can conclude that the rate is still very high compared to the rest of the world, especially first world countries. Thus, any preventive measures which are applied throughout the country must also be tailored to fit the needs of specific regions if they are to be truly effective.

Authors and Affiliations

Supriya Christopher, Giridhara Upadhyaya P. M

Keywords

EP ID EP284670
DOI 10.14260/jemds/2018/79
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