PREVALENCE OF HYPERAMYLASAEMIA IN OPC POISONING AND ITS CLINICAL SIGNIFICANCE- A CROSS-SECTIONAL STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 91
Abstract
BACKGROUND The incidence of organophosphorus poisoning has been steadily increasing and is typically endemic to developing countries like India, which has an economy based primarily on agriculture. The toxicity of organophosphorus compounds and the paucity of accessible medical facilities accounts for a high fatality rate. Their ease of access and several sociocultural factors play an important role in establishing organophosphorus compounds as a self-administered poison. The objective of this study is to estimate the prevalence of hyperamylasaemia in OPC poisoning and to determine its clinical significance. MATERIALS AND METHODS This was a cross-sectional study conducted in the Department of General Medicine in Govt. Vellore Medical College for a period of 3 months starting from 01 June 2016 to 31 August 2016. All patients aged 13 and above getting admitted in medical wards and in Intensive Care Unit attached to Department of General Medicine, GVMCH, Vellore with documented history of OPC poison consumption or exposure were included in the study. Information were collected through a preformed and pre-tested proforma from each patient. Qualifying patients underwent detailed history, clinical, biochemical and radiological examination. RESULTS Among 75 patients with OPC poisoning 30 patients (40%) had increased serum amylase levels, 14 (46.66%) out of 30 patients with hyperamylasaemia patients had elevated serum lipase levels. Out of 14 patients 7 patients (9.33%) had hyperlipasaemia, while 7 patients (9.33%) among 14 patients with hyperlipasaemia were diagnosed with acute pancreatitis proven by biochemical and radiological investigations. CONCLUSION Hyperamylasaemia is frequently seen in organophosphate poisoning. In the study population, 7 patients were proved to have acute pancreatitis as a complication of OPC poisoning.
Authors and Affiliations
Arcot Thanjan Maaran, Kumanur Ethirajulu Govindarajulu, Pillanallur Rajendran Saiprashanth, Parthasarathy Prathiba
Keywords
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- EP ID EP279151
- DOI 10.14260/jemds/2017/1411
- Views 106
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