Prevalence of scrub typhus in and around Vishakhapatnam, Andhra Pradesh as a cause of fever of unknown origin (FUO)
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 4
Abstract
Introduction: Scrub typhus is a rickettsial infection which is caused by Orientia tsutsugamushi. Diagnosis should be largely based on a high index of suspicion and careful clinical, laboratory and epidemiological evaluation. Delay in diagnosis can be fatal otherwise the treatment is simple, doxycycline being the drug of choice. Materials And Methods : Fever of unknown origin ( FUO) of two consequent year 2013 & 2014 for period of 5 months (August to December) were screened for scrub typhus by Rapid method immune chromatographic assay (SD Bioline Tsutsugamushi, one step developed using major surface protein 56 kDa antigen of representation O . tsutsugamushi). Results : Total 200 cases in year 2013 and 240 cases in year 2014, suspected FUO cases admitted in hospital, Scrub typhus antibodies were detected in 50/200 (25% in year 2013), 59/240 (24.4% in year 2014). Patients present with most common symptom fever (100%) with chills and rigors, Eschar finding is almost zero in all cases. Laboratory parameters showed, thrombocytopenia (72% in 2013, 68% in 2014), deranged liver function, Creatinine (52% in 2013, 48% in 2014), hypoalbuminemia (52% in 2013, 37% in 2014). Complications leading to death (4%) are seen in year 2013 but zero in year 2014. Dramatic response to doxycycline seen in nearly all patients. Conclusion: The present study emphasises the importance of scrub typhus among cases of FUO especially after rainy season and during early cooler months. Early detection and treatment leads to reduce in morbidity and mortality.
Authors and Affiliations
Dr. A. Kanchana
Keywords
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