Prevalence of the Genetic Mutation CYP2C8*5 in Selected Ethnic Groups in Southern Ghana
Journal Title: International Journal of Biochemistry Research & Review - Year 2016, Vol 12, Issue 3
Abstract
Aim: The study determined prevalence of clinically relevant CYP2C8*5 polymorphism in 80 unrelated individuals, from selected ethnic groups in Southern Ghana. Medical history on adverse drug reactions of the subjects and level of dependency on drugs metabolized by CYP2C8 enzyme was obtained by questionnaire. Allele Specific-PCR analyses were used to genotype CYP2C8*5 alleles in the study subjects. Results: Allelic frequency for CYP2C8*5 was 83.75% which was statistically significant (p<0.05). There was no significant difference (p> 0.05) in the prevalence of CYP2C8*5 allele within the ethnic groups. Also, there was no significant association (p >0.05) between CYP2C8*5 allele and reported ADRs. Many (88.75%) of the study subjects depended highly (>1-3x in a year) on drugs metabolized by CYP2C8. Conclusions: The high prevalence of CYP2C8*5 determined in the study population may indicate a high risk of toxicity in using drugs metabolize by CYP2C8 since CYP2C8*5 mutants have been reported to have a reduced enzymatic activity. This is the first reported study on prevalence of CYP2C8*5 in Ghanaians.
Authors and Affiliations
Charles Brown, Christopher Larbie, Dominic Selorm Yao Amuzu
Keywords
Related Articles
- EP ID EP351145
- DOI 10.9734/IJBCRR/2016/25680
- Views 150
- Downloads 0
Effects of Fermentation on Nutritional and Microbial Qualities of Ash Neutralized Roselle (Hibiscus sabdariffa L.)
The study was conducted to investigate the effect of fermentation on the nutritional and microbial qualities of Roselle calyces from two States in Nigeria. Roselle calyx was fermented naturally (FN), fermented with cocon...
Heavy Metals Effect on the Activity and Kinetics of Peroxidase Enzyme in Crude Extracts of Rosmarinus officinalis and Eruca sativa
The catalytic activities and kinetic parameters of the enzyme peroxidase (POX), extracted from two plant species namely Rosmarinus officinalis and Eruca sativa, were investigated in the presence and absence of various he...
Utilization of Fish Feeds by Côte d’Ivoire Fish Farmers and Its Influence on the Quantitative Competitive Commercial Fish Production
This study assesses the ability of fish feeds to produce competitive commercial fish in quantity. Three hundred and one (301) fish farms were surveyed in fifteen (15) regions of Côte d’Ivoire between May and November 201...
Effect of Storage Temperature on the Nutritional Compositions of Lactic Acid Bacteria Fermented Spicy Tigernut- Milk Drink
The fundamental benefit for consuming edible products is based on its nutritional compositions. Several factors affect the nutritional composition of diverse edible products. This study was carried out between August-Oct...
Alterations in the Bio-membrane of Libyodrilus violaceus following Exposure to Crude Oil and Its Fractions
We investigated changes in the lipid profile of clitellum and post-clitellum sections of earthworms (Libyodrilus violaceus) after exposure to different doses of crude oil (Bonny light blend) or its fractions for two-week...