Primary Plasma Cell Leukemia Presenting as Acute Kidney Disease
Journal Title: Journal of Chalmeda AnandRao Institute of Medical Sciences - Year 2018, Vol 15, Issue 1
Abstract
Plasma cell neoplasms represent 1.4-2% of all malignancies. Primary plasma cell leukemia (pPCL) is a rare and aggressive malignancy of plasma cells with a poor prognosis, constituting only 1-4% of all plasma cell neoplasms. pPCL is characterized by the presence of >2X109/ l peripheral blood plasma cells or plasmacytosis accounting for >20% of total leucocyte count. Direct renal involvement in pPCL is rarely reported with only few cases in the English literature. We present a case of 41 year old female came to outpatient department with complains of fever, cough and breathlessness since 3 days and multiple joint pains and fatigue since 1month. Patient was investigated for symptoms and peripheral blood smear revealed leucocytosis with 40% of plasma cells and thrombocytopenia. Complete urine examination revealed proteinuria and hematuria. Bone marrow aspiration and biopsy showed plasmacytosis and immunohistochemistry confirmed the diagnosis. As patient was in renal failure, dialysis was done. Renal biopsy revealed cast nephropathy. Chemotherapy with bortezomib was started. Despite an initial favourable response, the patient died within two weeks due to an infectious complication. pPCL has short unfavourable outcome, requiring the achievement of better data to improve the disease course.
Authors and Affiliations
Vidyadhara Rani P, Swetha Annaram
Keywords
Related Articles
- EP ID EP443112
- DOI -
- Views 144
- Downloads 0
Eschar - An important Clinical Clue in Febrile illness in Rural Setting
A 46 year old man presented with acute febrile illness of 7 days duration, he had been taking treat-ment on lines of enteric fever with multiple antibiotics, on examination was found to have a papular lesion on the back...
Extraskeletal Ewing’s Sarcoma/ Primitive Neuro Ectodermal Tumor: A rare Case Report
Introduction: Extraskeletal Ewing’s Sarcoma (EES) is an uncommon round cell malignant tumor of uncharacterized mesenchymal origin. Case Report: We present a rare case of extraskeletal ewing’s sarcoma of leg in a 15 year...
Quality of Life and Psychiatric Morbidity in Patients with Diabetes Mellitus
Background and Aim: Diabetes Mellitus is a complex medical condition with a chronic course. The number of people with Diabetes is increasing with time. Psychiatric co-morbidity is very high in Diabetes. The study aim was...
Reasons for Living in Patients Suffering from Chronic Mental Illnesses
Background: Chronic mental illnesses like schizophrenia, bipolar affective disorder, depression, alcoholism affect the reasons for living in such patients. This is a study done to findout the reasons for living in such c...
Effect of Sleep Deprivation on the Academic Performance and Cognitive Functions among the College Students: A Cross Sectional Study
Background: Sleep is an important biological necessity, College students often have erratic sleep schedules, poor sleep hygiene and poor sleep quality, which might affect their performance and cognitive functions. Object...