Production of Monoclonal Antibodies in Transgenic Plants
Journal Title: Journal of Advances in Biology & Biotechnology - Year 2017, Vol 12, Issue 1
Abstract
Antibodies are one of specialized immune protein and innovative therapeutic agents that provides effective alternatives to treating various human diseases. The existing fermenter based process of production of great value antibodies that have biomedical importance is costly, tedious and low yield obtained via purification process. So far different plant types such as vegetables, cereals and legume plants were used to produce important therapeutic proteins. Expression of antibody in transgenic plants might be a solution to successfully scale up therapeutic antibodies, and lower the production costs. This is due to cheap production cost of plants and large amount of yield would be obtained. This review aims to high light on the possibility and comparison to efficiently produce antibody in different plant organs. Also the review extends to over view the role of plants as a flexible expression system for antibody production, which we foresee to progress alongside the production platforms to manufacture specialized antibodies using transgenic plants.
Authors and Affiliations
Yohannes Besufekad, Pandian Malaiyarsa
Keywords
Related Articles
- EP ID EP318118
- DOI 10.9734/JABB/2017/31777
- Views 94
- Downloads 0
Gas Chromotography Mass Spectrometric Analysis and Molluscicidal Effect of Crude Saponin from Balanites aegyptiaca (L.) Del.
Crude Saponin extracted from the stem-bark of Balanites aegyptiaca was analysed using gas chromatography-mass spectrometry and also evaluated for its molluscicidal properties against Bulinus globosus and Biomphalaria pfe...
Relationships among Phenotypic Traits of Giant African Land Snails in Western region of Nigeria
The relatedness among three populations (A. achatina, A. fulica and A. marginata) of giant African land snails, a highly relished source of protein in West Africa was studied. Three hundred (300) matured snails consisti...
Phylogenic Analysis of NRPS and PKS Genes Associated with Antagonistic Micromonospora Rc5 and Streptomyces Ru87 Isolates
Aims: To invistigate phylogenic analysis of NRPS and PKS genes. To discover uncommon and novel types of actinomycetes isolated from Egyptian soils. Study Design: Fifty rare actinomycetes were isolated from Egyptian soi...
Thermophilic Bacteria as a Source of Novel Polymers for Biotechnological Applications
Aims: We analyzed thermotolerant bacterial isolates of thermophiles from various regions in South East coasts of India. Study Design: A total of forty three (9.6%) thermotolerant bacterial isolates of thermophiles were s...
PDMS Flow Cell for Monitoring Bacterial Adhesion Capacity of Escherichia coli O157:H7 in Beverages
Aims: To develop and standardize a polydimethylsiloxane (PDMS) flow cells for monitoring bacterial adhesion capacity of biofilm formation by Escherichia coli O157:H7 in Beverages industry. Study Design: PDMS chip was fa...