Prognostic factors of triple-negative inflammatory breast cancer based on SEER database
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 10
Abstract
"Objective To investigate the clinicopathological features and survival prognostic factors of patients with triple-negative inflammatory breast cancer (TNIBC). Methods The data of patients with TNIBC from 2010 to 2015 were obtained from SEER database, and univariate analysis, multivariate analysis and Kaplan-Meier survival analysis were performed using the “survival” package in R statistical software. Results A total of 4 268 cases of inflammatory breast cancer were collected, including 1 023 cases of triple-negative subtype. Compared with non-TNIBC patients,TNIBC patients had a lower proportion of whites in ethnic distribution, a higher proportion of histological grade Ⅲ, a higher proportion of AJCC stage Ⅲ, and more patients without distant metastases, and more likely to receive chemotherapy (P＜0.05). Univariate Cox analysis showed that laterality, tumor diameter, AJCC stage, M stage, surgery and chemotherapy may be the influencing factors of overall survival (OS) (P＜0.05). Multivariate Cox analysis showed that laterality, tumor diameter and surgery were independent risk factors for OS in TNIBC patients, and the smaller the tumor (28-989 mm, HR=1.565, 95%CI: 1.061-2.309, P=0.024; ＞989 mm, HR=1.911, 95%CI: 1.205-3.030, P=0.006), locating in the right side (HR=0.719, 95%CI: 0.560-0.923, P=0.010), and the surgical treatment (HR=0.609, 95%CI: 0.423-0.876, P=0.008) were associated with better prognosis. Conclusion Laterality, tumor diameter, and surgery are independent influencing factors for survival prognosis in patients with TNIBC, and the smaller the tumor, locating in the right side, and surgery are associated with better prognosis."
Authors and Affiliations
CHEN Shuyu, GAO Ya
Keywords
Related Articles
- EP ID EP749050
- DOI -
- Views 37
- Downloads 0
Moxibustion at Neiguan acupoint in the prevention of myocardial damage caused by chemotherapy in breast cancer
Objective To investigate the effect of moxibustion on Neiguan acupoint in preventing myocardial damage caused by anthracycline-based chemotherapy in breast cancer patients, and to explore the feasibility of moxibustion o...
Analysis of influencing factors of osteoporosis in postmenopausal patients with type 2 diabetes mellitus and construction of nomogram model
"<b>Objective</b> To explore the influencing factors of osteoporosis (OP) in postmenopausal patients with type 2 diabetes mellitus (T2DM), and try to establish a predictive model of nomogram in developing OP in postmenop...
Comparison of clinical efficacy between laparoscopic total gastrectomy and proximal gastrectomy in the treatment of adenocarcinoma of esophagogastric junction
<b>Objective</b> To compare the advantages and disadvantages of two different resection margins by observing the clinical efficacy of laparoscopic total gastrectomy (TG) and proximal gastrectomy(PG) for radical resection...
Effects of a single epidural injection of low-dose esketamine on perioperative sedation and analgesia during cesarean section
Objective To evaluate the analgesic and sedative effect of single epidural application of esketamine in cesarean section during perioperative period, and analyze the clinical application value of esketamine in cesarean s...
Expression and clinical significance of IGFBP7 and TGFβ1 in esophageal squamous cell carcinoma
"<b>Objective</b> To investigate the expression of insulin-like growth factor binding protein 7 (IGFBP7) and transforming growth factor β1(TGFβ1) in esophageal squamous cell carcinoma (ESCC) tissues and their possible me...