Prognostic implication of MYb-like, swirm and Mpn domain-containing protein-1 and Twist-1 in renal cell carcinoma
Journal Title: Journal of Interdisciplinary Histopathology - Year 2016, Vol 4, Issue 1
Abstract
Objective: The data available regarding the epithelial-mesenchymal transition (EMT) markers are little. This study aimed to evaluate the immunohistochemical expression of EMT markers; MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM-1) and Twist-1 in renal cell carcinoma (RCC), in a trial to find their role in the prognosis of such type of cancer. Methods: Immunoexpressions of MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM-1) and Twist-1 were assessed in tissue specimens of 50 patients with RCC, and correlated with other clinicopathological features. The findings and their correlations were statistically determined. Results: Low expression of MYSM-1 was negatively correlated with size of the tumor, primary tumor (pT) stage, Fuhrman grade (P < 0.001), age (P = 0.002), and lymph node metastases (P = 0.010). Immunoexpression of MYSM-1 was significantly correlated with distant metastases (P = 0.004), overall survival (OS) (P < 0.001), and local recurrence (P = 0.001). High expression of Twist-1 was positively correlated with pT stage, Fuhrman grade, lymph node, distant metastases, age (P < 0.001), clinical stage (P = 0.002), the presence of sarcomatous change (P = 0.004), and tumor size (P = 0.008). Immunoexpression of Twist-1 was significantly correlated with distant metastases (P = 0.009), OS (P < 0.001), and local recurrence (P = 0.003). Conclusion: Overexpression of Twist-1 is an indication of poor prognosis in patients with RCC, whereas that of MYSM-1 is a marker of good prognosis.
Authors and Affiliations
Ola Harb, Abdelmonem Hegazy, Maged Ali, Rasha Haggag
Keywords
Related Articles
- EP ID EP143748
- DOI 10.5455/jihp.20160226125558
- Views 81
- Downloads 0
On the use of human tissues in research and practice
A rare fi nding of coexisting fi broadenoma and duct ectasia in axillary ectopic breast tissue
Ectopic breast tissue (EBT) can present anywhere along the milk line from axilla to groin. It can harbor all the pathological conditions as that of the normal breast though incidence is very low. Fibroadenoma is rare in...
Eff ects of menopause and diabetes on the rat thyroid gland: A histopathological and stereological examining
Objective: Menopause is described as the arrest of the menstruation cycle and ending of reproductive potential. Diabetes mellitus (DM) occurs with Type 1 diabetes that is originated from the absence of insulin and Type 2...
Cytomegalovirus endometritis in a non-immunosuppressed patient presenting as recurrent pyometra: A case report
Cytomegalovirus infection of the female genital tract is a rare entity. We present a case of 70-year-old woman who came with recurrent pyometra but was otherwise in good health. Hysterectomy was done, and the endometrium...
Primary Well Differentiated Squamous Cell Carcinoma of Kidney: A Rare Entity
Cancers of the kidney and renal pelvis are the ninth most common malignant cancer and form the 12th most common cause of all cancer-related deaths. Among malignant renal tumors, squamous cell carcinoma is rare neoplasm a...