Prognostic risk factors for lymph node involvement in patients with endometrial cancer
Journal Title: Turkish Journal of Obstetrics and Gynecology - Year 2017, Vol 14, Issue 1
Abstract
Objective: We aimed to analyze variables affecting lymph node (LN) involvement and to assess the need for systematic lymphadenectomy in patients with endometrial cancer (EC). Materials and Methods: A single centre retrospective analysis was conducted in a total of 128 consecutive patients with EC who underwent systematic pelvic or combined pelvic and paraaortic lymphadenectomy between 2009 and 2012. Mann-Whitney U, chi-square, and Fisher’s exact test were used for univariate analyses when appropriate. Variables with a p value <0.05 in the univariate analysis were included into a multivariate logistic regression analysis. The effects of variables on LN involvement are reported using adjusted odds ratios (ORs) and 95% confidence intervals (CI). Results: In univariate analysis, grade 2-3, tumor size ≥3 cm, deep (≥50%) myometrial invasion, presence of cervical, adnexal or omental involvement, positive peritoneal cytology, open surgical approach (laparotomy), combined pelvic and paraaortic lymphadenectomy and number of total LNs removed (>30) were found associated with LN involvement. However, the number of total LNs removed (>30) was the only independent variable that predict LN involvement in multivariate analysis [OR: 15.08; 95% CI: (1.28-177.59); p=0.03]. Conclusion: This study demonstrates that the more LNs removed during staging of EC, the greater the probability of finding LN metastasis.
Authors and Affiliations
Tayfun Toptaş, Tayup Şimşek, Şeyda Karaveli
Keywords
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- EP ID EP240592
- DOI 10.4274/tjod.52385
- Views 134
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