PROGNOSTIC VALUE OF BLOOD MARKERS OF INFLAMMATION AND ENDOTHELIAL FUNCTION FOR ISCHEMIC HEART DISEASE IN PATIENTS WITH HYPERTENSION
Journal Title: INTERNATIONAL ACADEMY JOURNAL "Web of Scholar" - Year 2017, Vol 1, Issue 9
Abstract
Aim of the study is to determine the predictive value with respect to the development of coronary heart disease (CHD) of immune-inflammatory response and endothelial function activity, in patients with hypertension (HT) stage II. Methods: We examined 180 patients (men and women) with documented HT stage II. All surveyed people were divided into two groups: the first group consisted of 130 primary HT patients stage II without CHD, the average age of 56.5±0.5 years; a second comparison group - 50 patients with CHD combined with HT II stage, average age of 58.1±0.8 years. Results: The results of the ROC-analysis showed significantly higher (AUC = 0.87) (95 % CI AUC 0,812-0,915) predictive value ratio of IL-1β / IL-10 in the development of coronary artery disease in hypertensive patients, with an optimal distribution of the threshold of > 1.7 sensitivity was 64.0 % and specificity - 94.6 %. The high sensitivity (88.0 %), to the development of coronary artery disease in hypertensive patients was significantly (AUC = 0,84) ∆V100rg, found at the point of separation of< 88 % specificity was 66.2 %.
Authors and Affiliations
Valentyn Mochonyi
Keywords
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