PROGNOSTIC VALUE OF SEX-DETERMINING REGION Y-BOX 2 (SOX2) IN PROSTATE CANCER
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 6
Abstract
Objectives: The objectives of this study were to evaluate the expression of sex-determining region-Y BOX 2 (SOX2) markers and their association with clinicopathological parameters. Methods: A cross-sectional study was carried out to involve 90 specimens from patients diagnosed with prostatic cancer (PC) and benign prostatic hypertrophy (BPH) compared with positive control (human bronchial tissue for SOX2 marker) with each run. Results: The highest proportion of specimens of PC was graded ≤7 by Gleason grading system (53.3%). There were significant associations (p<0.05) between all this cancer stem cell marker results and prevalence of PC. Positive SOX2 marker result was significantly associated with bad prognostic sign (81.3%, p=0.001). This marker was highly sensitive (100%) specificity (82.4%), with high accuracy (90%). Conclusion: There was a significant expression of SOX2 in prostate adenocarcinomas. SOX2 can be considered as a key regulator of tumor progression, aggressive behavior, and metastasis. Furthermore, it is a reliable marker for the early diagnosis and the designed chemotherapy of prostate adenocarcinomas.
Authors and Affiliations
HADEEL I MOHASEN , BASIM SHEHAB AHMED
MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII FROM NOSOCOMIAL URINARY TRACT INFECTION: A CASE REPORT
 The worldwide emergence of multidrug-resistant (MDR) Acinetobacter baumannii and high morbidity and mortality associated with this infection,present a challenge to clinicians. Emergence of resistance to multiple classe...
SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL (2-OXO-3-(ARYLIMINO) INDOLIN-1-YL)-N-ARYL PROPANAMIDES AS ANTI-HUMAN IMMUNODEFICIENCY AGENTS
Objective: Acquired immunodeficiency syndrome (AIDS) was first identified in the Western world in 1981. Since then, AIDS has been increasingly wide spreading, its rapid worldwide dissemination brought about by modern mas...
ACUTE AND SUB-ACUTE DERMAL TOXICITY STUDIES OF MORINDA CITRIFOLIA L. FRUIT EXTRACT IN SPRAGUE DAWLEY RATS
 Objective: Morinda citrifolia is one of the most significant plants that are used in traditional medicine. However, details of the dermal toxicity of M.citrifolia are still undiscovered. The objective of this study is...
ASSESSMENT OF POTENTIAL DRUG INTERACTIONS AMONG HOSPITALIZED PATIENTS IN NEUROLOGY DEPARTMENT IN TERTIARY CARE HOSPITALS
Objective: This research was instigated to determine and assess the prevalence, severity, type, and the total number of potential drug interactions in the neurology department of two hospitals in India. Methods: The dat...
AN OVERVIEW OF MEDICINAL VALUE OF CURCUMA SPECIES
Curcuma is a genus of about 100 accepted species in the family Zingiberaceae that contains such species as turmeric and Siam tulip. They are native to Southeast Asia, southern China, ISSN (Online): 2319-7064 ISSN (Online...