PROGNOSTIC VALUE OF SEX-DETERMINING REGION Y-BOX 2 (SOX2) IN PROSTATE CANCER
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 6
Abstract
Objectives: The objectives of this study were to evaluate the expression of sex-determining region-Y BOX 2 (SOX2) markers and their association with clinicopathological parameters. Methods: A cross-sectional study was carried out to involve 90 specimens from patients diagnosed with prostatic cancer (PC) and benign prostatic hypertrophy (BPH) compared with positive control (human bronchial tissue for SOX2 marker) with each run. Results: The highest proportion of specimens of PC was graded ≤7 by Gleason grading system (53.3%). There were significant associations (p<0.05) between all this cancer stem cell marker results and prevalence of PC. Positive SOX2 marker result was significantly associated with bad prognostic sign (81.3%, p=0.001). This marker was highly sensitive (100%) specificity (82.4%), with high accuracy (90%). Conclusion: There was a significant expression of SOX2 in prostate adenocarcinomas. SOX2 can be considered as a key regulator of tumor progression, aggressive behavior, and metastasis. Furthermore, it is a reliable marker for the early diagnosis and the designed chemotherapy of prostate adenocarcinomas.
Authors and Affiliations
HADEEL I MOHASEN , BASIM SHEHAB AHMED
Keywords
Related Articles
- EP ID EP609012
- DOI -
- Views 131
- Downloads 0
DEVELOPMENT OF FROVATRIPTAN SUCCINATE MICROEMULSION FOR NASAL DELIVERY: OPTIMIZATION, IN VITRO AND IN VIVO EVALUATION
Objective: The main objective of the present research work was to develop, optimize, and characterize microemulsion (ME) of frovatriptan succinate to improve brain transport. Methods: The pseudoternary phase diagrams we...
DETERMINATION OF PHENYLEPHRINE HYDROCHLORIDE IN PHARMACEUTICAL PREPARATIONS USING SPECTROPHOTOMETRIC METHOD
Objective: A simple and sensitive spectrophotometric method has been presented for the determination of phenylephrine hydrochloride by coupling reaction with diazotized sulfacetamide sodium. Methods: The method is based...
ISOLATION, OPTIMIZATION, AND ANTITUMOR ACTIVITY OF L-ASPARAGINASE EXTRACTED FROM PECTOBACTERIUM CAROTOVORUM AND SERRATIA MARCESCENS ON HUMAN BREAST ADENOCARCINOMA AND HUMAN HEPATOCELLULAR CARCINOMA CANCER CELL LINES
Objectives: The objective of this research was to obtain isolates capable of producing a high yield of L-asparaginase enzyme and to evaluate the antitumor activity of the purified enzyme against different cancer and norm...
MOLECULAR TARGET AND THERAPEUTIC ASPECTS OF RHEUMATOID ARTHRITIS: A REVIEW.
 Rheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease. Cytokine plays a significant role in modulating the immune systemand specifically the inflammation. The role of cytokines in disease has led...
INFLUENCE OF DOSAGE ON RETENTION IN PATIENTS METHADONE MAINTENANCE THERAPY PROGRAM FOR MAINTENANCE PHASE OF H. ADAM MALIK MEDAN CENTRAL GENERAL HOSPITAL
  Objective: This study aims to see the effect of methadone dose on patient retention in following the program.Materials and Methods: This study is a clinical study with cross-sectional study design. Data obtained from...