Progress in clinical researches of platelet-rich plasma in the treatment of chronic refractory wounds
Journal Title: Chinese Journal of Blood Transfusion - Year 2022, Vol 35, Issue 10
Abstract
Cutaneous chronic wounds are a major global health burden in continuous growth due to population aging and the higher incidence of chronic diseases, such as diabetes. In the process of spontaneous wound healing, growth factors play a vital role. Thanks to the high content of growth factors in platelet rich plasma(PRP), more and more PRP has been used to treat chronic refractory wounds, including diabetic ulcer, pressure ulcer, venous ulcer, and burns, etc., and has achieved significant results. Given the short duration of local growth factor release in the wound when PRP is applied alone, some studies have combined PRP with different tissue biology materials, such as hyaluronic acid, chitosan, and chitosan derivatives, to achieve better therapeutic results. In this paper, the preparation method of PRP, the mechanism of growth factors, the effect of PRP on wound repair, the combined application of PRP with repair materials and the advantages and disadvantages of PRP are reviewed.
Authors and Affiliations
Wenjuan LI, Shuchao ZHANG
Keywords
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- EP ID EP738389
- DOI 10.13303/j.cjbt.issn.1004-549x.2022.10.025
- Views 47
- Downloads 0
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