Prolactin as an immunomodulatory factor in psoriatic arthritis
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0
Abstract
Prolactin (PRL) is a hormone synthesized and secreted by lactotroph cells in the anterior pituitary gland. There is also extrapituitary hormone secretion by many cells, including cells of the immune system. In physiological conditions PRL is responsible for lactogenesis and other processes associated with it. PRL plays a significant role during the immune response as a cytokine, affecting proliferation and differentiation of many immune system cells. The biological effect of the hormone depends on binding with the specific prolactin receptor PRL-R, and activation of the transcription factors of targeted genes. For T lymphocyte stimulated PRL, that factor is mainly the interferon regulatory factor (IRF-1), which gives the possibility of adjusting the prolactin immune response. Literature data indicate that hyperprolactinemia (HPRL) is one of the important factors in the pathogenesis and course of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis and Sjogren’s syndrome. HPRL is diagnosed in nearly one-third of these patients. However, only a few data indicate the role of prolactin in psoriatic arthritis (PsA), whose etiology and disease progression are not fully elucidated, and the diagnosis is very difficult. Currently there is indicated a pronounced connection between the course of HPRL and activity of PsA. It seems also to be interesting that, regardless of the PRL levels in serum of patients with PsA, administration of bromocriptine – drug-lowering hormone – improves joint and skin symptoms, which indicates a decrease in disease activity, and is a promising way of alternative therapy for psoriatic arthritis. However, the effect of PRL on the pathogenesis and the severity of psoriatic arthritis has not yet been fully understood and further research will provide a possibility to assess the prognostic and diagnostic significance of prolactin in patients with PsA.
Authors and Affiliations
Izabela Kokot, Lilla Pawlik-Sobecka, Sylwia Płaczkowska, Agnieszka Piwowar
Keywords
Related Articles
- EP ID EP67227
- DOI -
- Views 166
- Downloads 0
Rozwój metod otrzymywania komórek wytwarzających przeciwciała monoklonalne
Przeciwciała monoklonalne są biomolekułami o dużym znaczeniu naukowym i praktycznym. Tworzą zbiór przeciwciał o jednakowej swoistości i sile wiązania ponieważ są syntezowane przez komórki hybrydoma tworzące klon, czyli l...
Meropenem – therapeutic recommendation after twenty years of presence on pharmaceutical market
Meropenem is the first representative of carbapenem analogues with methyl group, which has been applied in medicine. This drug has been approved by FDA (Food and Drug Administration) in 1996. Available results of clinica...
Vegetables and fruit, as a source of bioactive substances, and impact on memory and cognitive function of elderly
The phenomenon of population aging is not only associated with an increase in the number and proportion of older people in society, but also with an increase in the incidence of cognitive impairment. This can impair the...
Epidemiologia Yersinia enterocolitica ze szczególnym uwzględnieniem rezerwuaru zwierzęcego
Do rodzaju Yersinia należą Gram–ujemne pałeczki obejmujące obecnie 18 gatunków. Yersinia enterocolitica to psychotrofowa pałeczka, która jest patogenem posiadającym wiele czynników wirulencji umożliwiających zarówno adhe...
Classical oxazaphosphorines – metabolism and therapeutic properties – new implications
Cyclophosphamide (CPA) and ifosfamide (IFO) belong to oxazaphosphorine drugs and for a few decades have been widely used for treatment of solid tumours and haematological malignancies. Both drugs are administered in phar...