Prolonged High-Fat Diet Feeding of WHHLMI Rabbits does Not Aggravate Metabolic or Cardiac Dysfunction
Journal Title: Journal of Diabetes and Obesity - Year 2018, Vol 5, Issue 1
Abstract
emsp emsp Myocardial infarction MI -prone Watanabe hereditary hyperlipidemic WHHLMI rabbits were reported to spontaneously but slowly develop MI associated with enhanced coronary atherosclerosis and metabolic syndrome features Our aim was to accelerate these processes by exposing the rabbits to a high-fat diet HFD that was previously shown to induce insulin resistance and cardiac injury in rabbits emsp emsp HFD feeding for one year was indeed associated with development of obesity 37 increases in body weight as compared to 3 7 for control standard-fat diet SFD On HFD liver weight and hepatic triglyceride content were significantly higher as compared to SFD with mild steatosis Glucose and insulin levels were not markedly different on SFD or HFD however after 1 year of diet treatment HFD-fed animals were more glucose intolerant as compared to SFD-fed rabbits On SFD the rabbits developed marked thoracic aorta stenosis and calcification of atherosclerotic lesions which were not aggravated by HFD feeding Cardiac function analysis by MRI and transthoracic echocardiography did not reveal significant differences between SFD and HFD fed rabbits emsp emsp Thus the metabolic and cardiac phenotype of WHHLMI rabbits was not aggravated by HFD feeding for one year and the rabbits did not spontaneously develop diabetes or myocardial infarction
Authors and Affiliations
Bianca Hemmeryckx
Keywords
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- EP ID EP418297
- DOI 10.15436/2376-0494.18.1803
- Views 127
- Downloads 0
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