Prophylactic effect of lithium in bipolar affective illness may be related to serotonin transporter genotype.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 1
Abstract
Serotonin transporter promoter length polymorphism (5-HTTLPR) has been implicated in the pathogenesis of mood disorders and in the therapeutic response to serotonergic drugs. In this study, the 5-HTTLPR was estimated in 67 patients with bipolar mood disorder, receiving lithium carbonate for prophylactic purposes for the period of more than 5 years (mean 15 years). The patients were divided into excellent responders (n = 18), partial responders (n = 35) and poor responders (n = 14). In lithium non-responders, the genotype s/s and the allele s was significantly more frequent than in excellent and partial responders. The obtained results are discussed in view of other studies showing an association of S genotype with worse response to serotonergic drugs. A supposition is made that prophylactic management of bipolar illness can be optimized by defining 5-HTTLPR genotype.
Authors and Affiliations
Janusz Rybakowski, Aleksandra Suwalska, Piotr Czerski, Monika Dmitrzak-Weglarz, Anna Leszczynska-Rodziewicz, Joanna Hauser
Keywords
Related Articles
- EP ID EP154519
- DOI -
- Views 124
- Downloads 0
Enhanced anti-ulcer effect of pioglitazone on gastric ulcers in cirrhotic rats: The role of nitric oxide and IL-1β.
Background: The frequency of gastrointestinal ulcerations is higher in cirrhotic patients than in the normal population. It has been shown that pioglitazone exhibits gastroprotective actions. This study was designed to i...
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro.
A detailed comprehension of central mechanisms underlying feeding behavior holds considerable promise for the treatment of alimentary disorders.
Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy.
Asymmetric dimethylarginine (ADMA) is synthesized during the methylation of protein arginine residues by protein arginine methyltransferases (PRMT) and is released during proteolysis. ADMA is a competitive inhibitor of n...
Influence of long-term treatment with tuftsin analogue TP-7 on the anxiety-phobic states and body weight.
TP-7 is a synthetic analogue of tuftsin. It has a structure of tuftsin, to which three natural L-amino-acids Pro-Gly-Pro are attached. This heptapeptide improves learning and memorization and causes antidepressant and an...
Synergistic interaction of gabapentin with tiagabine in the hot-plate test in mice: an isobolographic analysis.
This study was aimed at determining the analgesic effect of gabapentin and tiagabine, two antiepileptic drugs that were administered alone and in combination at a fixed ratio of 1:1, in the acute thermal pain model (hot-...