Prophylactic Intravenous Glycopyrrolate Bromide and its cardio-protective role in Laparoscopic Cholecystectomy
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 7
Abstract
Background: Gallstones are the most common & costly digestive disease, it is estimated that more than one million new cases emerge annually worldwide. Since there is little known about the role of Glycopyrrolate in laparoscopic surgeries; this study focuses on prophylactic role of Glycopyrrolate Bromide in prevention of bradycardia during laparoscopic cholecystectomy. Materials and methods: Prospective, randomized, double blind comparative study was designed to include 50 patients. Control group (25 patients) was given 1 ml of normal saline and Glycopyrrolate group 1ml = 0.2 mg of Glycopyrrolate during induction of anaesthesia. Data of Heart rate, Systolic and Diastolic Blood Pressure, Mean Arterial Pressure were taken in following manner: baseline (B); 1min after drug / normal Saline (Agent 1); 1 & 5 mins after intubation respectively (I 1 & 5); 1,3,5,15 & 30 mins after Pneumoperitoneum respectively (P ;1,3,5,15 & 30); Before Extubation (E b); After Extubation (E a). Results: There was a significant difference in heart rate specially after one, three and five minutes of pneumoperitoneum between group p and g (p < 0.05). Diastolic and systolic blood pressure, in both groups also did not changed significantly following administration of agent and event after laryngoscopy and intubation. In both groups heart rate, systolic blood pressure & diastolic blood pressure increased after extubation, but were within acceptable range; comparison between the two groups was not significant. Conclusion: Preoperative glycopyrrolate as premedication has a cardioprotective role and should be considered during laparoscopic cholecystectomy to prevent these disastrous consequences which has potential to take life of otherwise healthy individual.
Authors and Affiliations
Shirish Prasad Amatya, Anil Shrestha, Roshan Piya, Manisha Pradhan, Niroj Hirachan, Jay Prakash Thakur
Keywords
Related Articles
- EP ID EP558579
- DOI -
- Views 120
- Downloads 0
STUDY OF CLINICAL, RADIOLOGICAL AND BACTERIOLOGICAL PROFILE OF COMMUNITY ACQUIRED PNEUMONIA AND ASSESSMENT OF SEVERITY IN DIABETIC AND NON-DIABETIC PATIENT
Patients with diabetes are immune compromised. It has been suggested that diabetes mellitus is associated with an increased susceptibility to infections, therisk of using more aggressive therapeutic agents and increase...
Assessment of Periodontal Health in Patients with Sickle Cell Disease (SCD)
Background: Sickle cell disease (SCD) is an inherited disease in individuals homozygous for hemoglobin S. Numerous oral manifestations of SCD that affect the oral mucosa, gingival tissue, mandible, nerve supply, and toot...
ULTRASONOGRAPHY AS AN IMAGING TECHNIQUE FOR THE DIAGNOSIS OF GALL BLADDER DISORDERS: A CLINICAL STUDY
Background: Pain in abdominal may be due to abnormalities in gall bladder, kidneys, pancreas, stomach, duodenum, spleen etc. Cholecystitis and cholelithiasis are common disorder and is usually asymptomatic. Ultrasound is...
Estimation of Concentration of Nickel and Chromium in the GCF of patients with Fixed Orthodontics
Background: Fixed orthodontic appliances usually include brackets, bands, arch wires, and springs. They are made of stainless steel, nickel–titanium, or nickel-cobalt alloys. The stainless steel currently used in orthodo...
A Study on the Use of Gingival Crevicular Blood for Measuring Glucose to Screen for Diabetes and Comparison of Measurements of Glycated Hemoglobin in Periodontitis Cases and Gingivitis Subjects
Aim- Diabetes mellitus and chronic periodontitis are the most common chronic diseases in the adult world population. Many people suffering from diabetes around the globe do not know that they have diabetes. A dental / pe...